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1. WO2009052971 - COMPLEXES OF TRPC DOMAINS AND SESTD1 DOMAINS AND METHODS AND USES INVOLVING THE SAME

Publication Number WO/2009/052971
Publication Date 30.04.2009
International Application No. PCT/EP2008/008670
International Filing Date 14.10.2008
IPC
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
CPC
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
G01N 2405/04
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2405Assays, e.g. immunoassays or enzyme assays, involving lipids
04Phospholipids, i.e. phosphoglycerides
Applicants
  • SANOFI-AVENTIS [FR]/[FR] (AllExceptUS)
  • MIEHE, Susanne [DE]/[DE] (UsOnly)
  • STRUEBING, Carsten [DE]/[DE] (UsOnly)
Inventors
  • MIEHE, Susanne
  • STRUEBING, Carsten
Agents
  • SCHNEIDER, Rudolf
Priority Data
07291300.726.10.2007EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPLEXES OF TRPC DOMAINS AND SESTD1 DOMAINS AND METHODS AND USES INVOLVING THE SAME
(FR) COMPLEXES DE DOMAINES TRPC ET DE DOMAINES SESTD1 ET PROCÉDÉS ET UTILISATIONS LES IMPLQUANT
Abstract
(EN)
The present invention relates to an isolated complex comprising a first protein comprising or consisting of a classical transient receptor potential channel (TRPC) or a functionally active variant thereof and a second protein comprising or consisting of the first spectrin (Spec 1) domain of SEC14 and spectrin domains 1 (SESTD1), a test system comprising the first protein and the second protein as well as means for detecting interaction of the first and the second protein, a method for screening for a TRPC modulator using the system and the use of the test system for the identification of a TRPC modulator.
(FR)
L'invention concerne un complexe isolé comprenant une première protéine comprenant ou consistant en un canal potentiel de récepteur transitoire (TRPC) classique ou une variante fonctionnellement active de celui-ci et une seconde protéine composée ou constituée par le premier domaine de spectrine (Spec 1) de SEC14 et les domaines 1 de spectrine (SESTD1), un système d'essai comprenant la première et la seconde protéine ainsi que des moyens de détection de l'interaction de la première et de la seconde protéine, un procédé de criblage d'un modulateur TRPC utilisant le système et l'utilisation du système d'essai pour identifier un modulateur TRPC.
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