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1. (WO2009051671) IMPROVED METHODS OF PRODUCING RPE CELLS AND COMPOSITIONS OF RPE CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2009/051671 International Application No.: PCT/US2008/011669
Publication Date: 23.04.2009 International Filing Date: 10.10.2008
IPC:
C12N 5/02 (2006.01) ,C12N 5/071 (2010.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
02
Propagation of single cells or cells in suspension; Maintenance thereof; Culture media therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
Applicants:
MALCUIT, Christopher [US/US]; US (UsOnly)
LEMIEUX, Linda [US/US]; US (UsOnly)
HOLMES, Willliam [US/US]; US (UsOnly)
HUERTAS, Pedro [US/US]; US (UsOnly)
VILNER, Lucy [US/US]; US (UsOnly)
ADVANCED CELL TECHNOLOGY, INC. [US/US]; 381 Plantation Street Biotech V Worcester, MA 01605, US (AllExceptUS)
Inventors:
MALCUIT, Christopher; US
LEMIEUX, Linda; US
HOLMES, Willliam; US
HUERTAS, Pedro; US
VILNER, Lucy; US
Agent:
TESKIN, Robin, L.; Hunton & Williams 1900 K Street, N.W. Washington, D.C. 20006, US
Priority Data:
60/998,66812.10.2007US
60/998,76612.10.2007US
61/009,90802.01.2008US
61/009,91102.01.2008US
Title (EN) IMPROVED METHODS OF PRODUCING RPE CELLS AND COMPOSITIONS OF RPE CELLS
(FR) PROCÉDÉS AMÉLIORÉS POUR LA PRODUCTION DE CELLULES RPE ET DE COMPOSITIONS DE CELLULES RPE
Abstract:
(EN) The present invention provides improved methods for producing RPE cells from human embryonic stem cells or from other human pluripotent stem cells. The invention also relates to human retinal pigmented epithelial cells derived from human embryonic stem cells or other human multipotent or pluripotent stem cells. hRPE cells derived from embryonic stem cells are molecularly distinct from adult and fetal-derived RPE cells, and are also distinct from embryonic stem cells. The hRPE cells described herein are useful for treating retinal degenerative diseases.
(FR) La présente invention concerne des procédés améliorés pour la production de cellules RPE à partir de cellules souches d'embryon humain ou d'autres cellules souches pluripotentes humaines. L'invention a également pour objets des cellules épithéliales pigmentées de rétine humaine (hRPE) dérivées de cellules souches d'embryon humain ou d'autres cellules souches multipotentes ou pluripotentes humaines. Les cellules hRPE dérivées de cellules souches embryonnaires sont distinctes d'un point de vue moléculaire des cellules RPE dérivées d'adultes et de fœtus, et sont également distinctes des cellules souches embryonnaires. Les cellules hRPE décrites dans les présentes sont utiles au traitement de maladies dégénérescentes de la rétine.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)