WO2009051671 IMPROVED METHODS OF PRODUCING RPE CELLS AND COMPOSITIONS OF RPE CELLS

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Publication Number WO/2009/051671

Publication Date 23.04.2009

International Application No. PCT/US2008/011669

International Filing Date 10.10.2008

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Applicants

ADVANCED CELL TECHNOLOGY, INC. [US]/[US] (AllExceptUS)
MALCUIT, Christopher [US]/[US] (UsOnly)
LEMIEUX, Linda [US]/[US] (UsOnly)
HOLMES, Willliam [US]/[US] (UsOnly)
HUERTAS, Pedro [US]/[US] (UsOnly)
VILNER, Lucy [US]/[US] (UsOnly)

Inventors

MALCUIT, Christopher
LEMIEUX, Linda
HOLMES, Willliam
HUERTAS, Pedro
VILNER, Lucy

Agents

TESKIN, Robin, L.

Priority Data

60/998,668	12.10.2007	US
60/998,766	12.10.2007	US
61/009,908	02.01.2008	US
61/009,911	02.01.2008	US

Publication Language English (en)

Filing Language English (EN)

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Title

(EN) IMPROVED METHODS OF PRODUCING RPE CELLS AND COMPOSITIONS OF RPE CELLS

(FR) PROCÉDÉS AMÉLIORÉS POUR LA PRODUCTION DE CELLULES RPE ET DE COMPOSITIONS DE CELLULES RPE

Abstract

(EN) The present invention provides improved methods for producing RPE cells from human embryonic stem cells or from other human pluripotent stem cells. The invention also relates to human retinal pigmented epithelial cells derived from human embryonic stem cells or other human multipotent or pluripotent stem cells. hRPE cells derived from embryonic stem cells are molecularly distinct from adult and fetal-derived RPE cells, and are also distinct from embryonic stem cells. The hRPE cells described herein are useful for treating retinal degenerative diseases.

(FR) La présente invention concerne des procédés améliorés pour la production de cellules RPE à partir de cellules souches d'embryon humain ou d'autres cellules souches pluripotentes humaines. L'invention a également pour objets des cellules épithéliales pigmentées de rétine humaine (hRPE) dérivées de cellules souches d'embryon humain ou d'autres cellules souches multipotentes ou pluripotentes humaines. Les cellules hRPE dérivées de cellules souches embryonnaires sont distinctes d'un point de vue moléculaire des cellules RPE dérivées d'adultes et de fœtus, et sont également distinctes des cellules souches embryonnaires. Les cellules hRPE décrites dans les présentes sont utiles au traitement de maladies dégénérescentes de la rétine.

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5	Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
02	Propagation of single cells or cells in suspension; Maintenance thereof; Culture media therefor

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5	Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07	Animal cells or tissues
071	Vertebrate cells or tissues, e.g. human cells or tissues

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5	Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
02	Propagation of single cells or cells in suspension; Maintenance thereof; Culture media therefor

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5	Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07	Animal cells or tissues
071	Vertebrate cells or tissues, e.g. human cells or tissues

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35	Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12	Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

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1. WO2009051671 - IMPROVED METHODS OF PRODUCING RPE CELLS AND COMPOSITIONS OF RPE CELLS

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25	Drugs for disorders of the nervous system
14	for treating abnormal movements, e.g. chorea, dyskinesia
16	Anti-Parkinson drugs