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1. WO2009047791 - TOLL LIKE RECEPTOR (TLR) SIGNALING ANTAGONIST

Publication Number WO/2009/047791
Publication Date 16.04.2009
International Application No. PCT/IN2008/000608
International Filing Date 24.09.2008
IPC
C07C 43/23 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
43Ethers; Compounds having groups, groups or groups
02Ethers
20having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
23containing hydroxy or O-metal groups
C07C 69/157 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
02Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
12Acetic acid esters
14of monohydroxylic compounds
145of unsaturated alcohols
157containing six-membered aromatic rings
C07C 43/20 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
43Ethers; Compounds having groups, groups or groups
02Ethers
20having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
C07C 69/73 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
66Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, -CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
73of unsaturated acids
A61K 31/09 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
075Ethers or acetals
085having an ether linkage to aromatic ring nuclear carbon
09having two or more such linkages
A61K 31/215 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
CPC
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 17/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
10Anti-acne agents
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
Applicants
  • RELIANCE LIFE SCIENCES PVT. LTD. [IN]/[IN] (AllExceptUS)
  • SHAKTI, Upadhyay [IN]/[IN] (UsOnly)
  • YOGESH, Kanekar [IN]/[IN] (UsOnly)
  • RAJENDRA, Kshirsagar [IN]/[IN] (UsOnly)
  • VIKRAM, Rajagopal [IN]/[IN] (UsOnly)
  • PRANEEL, Datla [IN]/[IN] (UsOnly)
  • AKSHAYA, Bellary [IN]/[IN] (UsOnly)
  • SHIVA, Prasa, Singh [IN]/[IN] (UsOnly)
Inventors
  • SHAKTI, Upadhyay
  • YOGESH, Kanekar
  • RAJENDRA, Kshirsagar
  • VIKRAM, Rajagopal
  • PRANEEL, Datla
  • AKSHAYA, Bellary
  • SHIVA, Prasa, Singh
Priority Data
1853/MUM/200724.09.2007IN
2541/MUM/200724.12.2007IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TOLL LIKE RECEPTOR (TLR) SIGNALING ANTAGONIST
(FR) ANTAGONISTE DE SIGNALISATION DE RÉCEPTEURS DE TYPE TOLL (TLR)
Abstract
(EN)
The present invention relates to novel synthetic toll like receptor antagonist. The present invention in particular provides compounds, methods and compositions for specifically inhibiting immune stimulation involving TLR ligands, especially TLR-4. The compounds are potentially useful in treatment of inflammation, autoimmunity, allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.
(FR)
La présente invention concerne un nouvel antagoniste des récepteurs de type Toll (TLR). La présente invention concerne en particulier des composés, des méthodes et des compositions permettant d'inhiber spécifiquement une stimulation immunitaire impliquant des ligands de TLR, notamment de TLR-4. Lesdits composés sont potentiellement utiles dans le traitement de l'inflammation, de l'auto-immunité, de l'allergie, de l'asthme, du rejet de greffe, de la maladie du greffon contre l'hôte, de l'infection, du sepsis, du cancer et de l'immunodéficience.
Also published as
Latest bibliographic data on file with the International Bureau