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1. WO2009047515 - METHOD OF IDENTIFYING CANCER RISK MARKERS

Publication Number WO/2009/047515
Publication Date 16.04.2009
International Application No. PCT/GB2008/003430
International Filing Date 10.10.2008
IPC
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
Applicants
  • JENKINS, Paul [GB]/[GB]
Inventors
  • JENKINS, Paul
Agents
  • GILL JENNINGS & EVERY LLP
Priority Data
0719809.610.10.2007GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF IDENTIFYING CANCER RISK MARKERS
(FR) PROCÉDÉ D'IDENTIFICATION DE MARQUEURS DE RISQUE CANCÉREUX
Abstract
(EN)
A method of identifying one or more markers for the risk of cancer comprising the steps of: (i) comparing gene expression in a first tissue sample obtained from a non-cancer patient, to gene expression in a second tissue sample from corresponding tissue from a patient having been diagnosed with a cancer in that tissue, wherein the first tissue is the same tissue type as the second tissue and the second tissue sample does not comprise cancerous tissue; and (ii) identifying genes that are differentially expressed between the two samples, wherein the differentially expressed gene is a marker for the risk of the cancer.
(FR)
La présente invention concerne un procédé d'identification d'un ou de plusieurs marqueurs permettant de déterminer le risque cancéreux. Ledit procédé consiste: (i) à comparer l'expression génique d'un premier échantillon de tissu prélevé sur un patient sain, à l'expression génique d'un second échantillon de tissu provenant du tissu correspondant prélevé sur un patient chez lequel a été diagnostiqué un cancer dans ledit tissu. Le premier tissu est du même type que le second tissu, et le second échantillon de tissu ne renferme pas de tissu cancéreux. Ledit procédé consiste en outre: (ii) à identifier des gènes qui sont exprimés différentiellement entre les deux échantillons, le gène exprimé différentiellement étant un marqueur du risque cancéreux.
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