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1. WO2009047290 - USE OF QUATERNARY PYRIDINIUM SALTS FOR RADIOPROTECTION

Publication Number WO/2009/047290
Publication Date 16.04.2009
International Application No. PCT/EP2008/063534
International Filing Date 09.10.2008
IPC
A61K 31/4425 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4425Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
A61P 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
39General protective or antinoxious agents
CPC
A61K 31/4425
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
4425Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
A61P 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
39General protective or antinoxious agents
A61P 39/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
39General protective or antinoxious agents
06Free radical scavengers or antioxidants
Applicants
  • POLITECHNIKA LODZKA [PL]/[PL] (AllExceptUS)
  • UNIWERSYTET JAGIELLONSKI [PL]/[PL] (AllExceptUS)
  • GEBICKI, Jerzy [PL]/[PL] (UsOnly)
  • MARCINEK, Andrzej [PL]/[PL] (UsOnly)
  • CHLOPICKI, Stefan [PL]/[PL] (UsOnly)
  • JANIAK, Marek [PL]/[PL] (UsOnly)
Inventors
  • GEBICKI, Jerzy
  • MARCINEK, Andrzej
  • CHLOPICKI, Stefan
  • JANIAK, Marek
Agents
  • SITKOWSKA, Jadwiga
Priority Data
07465007.812.10.2007EP
08465001.909.01.2008EP
60/998,85612.10.2007US
61/010,48709.01.2008US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) USE OF QUATERNARY PYRIDINIUM SALTS FOR RADIOPROTECTION
(FR) UTILISATION DE SELS DE PYRIDINIUM QUATERNAIRE POUR LA RADIOPROTECTION
Abstract
(EN)
A method for the treatment or prevention of a cell or tissue damage in a living subject due to the exposure to ionizing radiation is provided, which comprises administration to said subject of a quaternary pyridinium salt of formula (I) wherein R' is H, OH, CONH2 or COCH3, R' is H or CH3, R'' is H or CH3, and X- is a pharmaceutically acceptable counterion, in an amount sufficient to inhibit radiation-induced damage.
(FR)
L'invention concerne un procédé permettant de traiter ou de prévenir une lésion cellulaire ou tissulaire chez un sujet vivant, due à l'exposition à un rayonnement ionisant. Le procédé consiste à administrer audit sujet un sel de pyridinium quaternaire de formule (I), R' représentant H, OH, CONH2 ou COCH3, R'' représentant H ou CH3, R''' représentant H ou CH3 et X- représentant un contre-ion pharmaceutiquement acceptable, en quantité suffisante pour inhiber la lésion induite par le rayonnement.
Also published as
Latest bibliographic data on file with the International Bureau