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1. (WO2009046984) HIV PREVENTIVE VACCINE BASED ON HIV SPECIFIC ANTIBODIES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2009/046984 International Application No.: PCT/EP2008/008544
Publication Date: 16.04.2009 International Filing Date: 09.10.2008
Chapter 2 Demand Filed: 01.07.2009
IPC:
C12N 15/10 (2006.01) ,A61K 39/21 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
10
Processes for the isolation, preparation or purification of DNA or RNA
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
21
Retroviridae, e.g. equine infectious anemia virus
Applicants:
TECHNOLOGIE INTEGRALE LTD. [AT/AT]; Masonic Buildings Water St Ramsey IM8 1RD Isle of Man, GB (AllExceptUS)
FILINOVA, Elena, Yu. [RU/RU]; RU (UsOnly)
Inventors:
FILINOVA, Elena, Yu.; RU
Agent:
BECKER KURIG STRAUS; Bavariastr. 7 80336 Munich, DE
Priority Data:
60/978,53609.10.2007US
Title (EN) HIV PREVENTIVE VACCINE BASED ON HIV SPECIFIC ANTIBODIES
(FR) VACCIN PRÉVENTIF CONTRE VIH À BASE D'ANTICORPS SPÉCIFIQUE DE VIH
Abstract:
(EN) The present invention relates to a method for producing a HIV vaccine, preventing infection with HIV and/or preventing the development of HIV infection in an individual. In particular, the present invention provides formation of HIV specific antibodies capable to recognize and bind to substantially all HIV-isoforms as an immune response in an individual, which bind to existing in a current epidemiologic cohort HIV-subtypes and mutants selected after antiretroviral therapy. The present invention also relates to HIV-1 peptides/polypeptides/proteins selection with reverse panning technique, LC mass spectrometry identification of HIV-1 env peptides/polypeptides/proteins, gp120 and its fragment in particular, production of recombinant HIV-1 env peptides in suitable host with necessary glycosylation - L. tarentolae and using sterically stabilized liposomes (SSL) as an adjuvant-carrier for HIV-specific immune boost composition.
(FR) La présente invention concerne un procédé de production d'un vaccin contre le VIH, de prévention d'une infection à VIH et/ou de prévention du développement d'une infection à VIH chez un individu. En particulier, la présente invention concerne la formation d'anticorps spécifiques de VIH capables de reconnaître et de se lier substantiellement à toutes les isoformes de VIH en tant que réponse immunitaire chez un individu, qui se lient à des sous-types de VIH existants dans une cohorte épidémiologique actuelle et des mutants choisis après un traitement antirétroviral. La présente invention concerne également la sélection de peptides/polypeptides/protéines de VIH-1 par une technique d'adhérence inverse, identification par spectrométrie de masse LC de peptides/polypeptides/protéines de VIH-1 env, gp120 et leur fragment, en particulier, la production de peptides de VIH-1 env recombinants chez un hôte approprié avec une glycosylation nécessaire - L. tarentolae et en utilisant des liposomes stériquement stabilisés (SSL) comme adjuvant-véhicule pour la composition de stimulation immunitaire spécifique de VIH.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)