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1. WO2009046129 - METHODS FOR TREATING ADULT RESPIRATORY DISTRESS SYNDROME

Publication Number WO/2009/046129
Publication Date 09.04.2009
International Application No. PCT/US2008/078483
International Filing Date 01.10.2008
IPC
C12N 9/96 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
96Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
C12N 9/12 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
C07K 2/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2Peptides of undefined number of amino acids; Derivatives thereof
CPC
A61K 31/7016
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7016Disaccharides, e.g. lactose, lactulose
A61K 33/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
24Heavy metals; Compounds thereof
A61K 33/30
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
24Heavy metals; Compounds thereof
30Zinc; Compounds thereof
A61K 33/34
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
24Heavy metals; Compounds thereof
34Copper; Compounds thereof
A61K 38/45
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
45Transferases (2)
A61K 47/52
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
52the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
Applicants
  • COLUMBIA UNIVERSITY [US]/[US] (AllExceptUS)
  • BHATTACHARYA, Jahar [US]/[US] (UsOnly)
  • QUADRI, Sadiqa [US]/[US] (UsOnly)
  • DAS, Shonit [US]/[US] (UsOnly)
Inventors
  • BHATTACHARYA, Jahar
  • QUADRI, Sadiqa
  • DAS, Shonit
Agents
  • EVANS, Judith
Priority Data
60/976,77901.10.2007US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR TREATING ADULT RESPIRATORY DISTRESS SYNDROME
(FR) PROCÉDÉS DE TRAITEMENT DU SYNDROME DE DÉTRESSE RESPIRATOIRE DE L'ADULTE
Abstract
(EN)
We have discovered that the activated phosphorylated form of focal adhesion kinase (hereafter 'FAKp') strengthens the microvascular endothelial cell (EC) junctions that form a barrier in pulmonary endothelia, and the increased barrier helps to prevent acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Thus certain embodiments of the invention are directed to prevention and treatment of ALI and ARDS by administering a therapeutically effective amount of FAKp to subjects at risk of developing or diagnosed as having either ALI or ARDS.
(FR)
L'invention concerne la forme phosphorylée activée d'une kinase à adhérence focale (ci-après « FAKp ») qui renforce les jonctions de cellule endothéliale (EC) microvasculaire qui forment une barrière dans l'endothélium pulmonaire, et la barrière accrue qui aide à empêcher une lésion pulmonaire aiguë (LPA) et le syndrome de détresse respiratoire aigu (SDRA). Ainsi, certains modes de réalisation de l'invention concernent la prévention et le traitement d'une LPA et d'un SDRA par l'administration d'une quantité thérapeutiquement efficace de FAKp à des sujets présentant un risque de développer, ou diagnostiqués comme présentant, soit une LPA soit un SDRA.
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Latest bibliographic data on file with the International Bureau