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1. WO2009027283 - TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS

Publication Number WO/2009/027283
Publication Date 05.03.2009
International Application No. PCT/EP2008/060884
International Filing Date 20.08.2008
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
C07D 471/04 (2006.01)
A61K 31/437 (2006.01)
A61P 29/00 (2006.01)
CPC
C07D 471/04
Applicants
  • MERCK SERONO S.A. [CH/CH]; Centre Industriel CH-1267 Coinsins, CH (AllExceptUS)
  • SWINNEN, Dominique [BE/FR]; FR (UsOnly)
  • JORAND-LEBRUN, Catherine [FR/FR]; FR (UsOnly)
  • GRIPPI - VALLOTTON, Tania [CH/CH]; CH (UsOnly)
  • MUZERELLE, Mathilde [FR/FR]; FR (UsOnly)
  • ROYLE, Amanda [GB/GB]; GB (UsOnly)
  • MACRITCHIE, Jacqueline [GB/GB]; GB (UsOnly)
  • HILL, Richard [GB/GB]; GB (UsOnly)
  • SHAW, Jeffrey P. [IT/CH]; CH (UsOnly)
Inventors
  • SWINNEN, Dominique; FR
  • JORAND-LEBRUN, Catherine; FR
  • GRIPPI - VALLOTTON, Tania; CH
  • MUZERELLE, Mathilde; FR
  • ROYLE, Amanda; GB
  • MACRITCHIE, Jacqueline; GB
  • HILL, Richard; GB
  • SHAW, Jeffrey P.; CH
Agents
  • MERCK SERONO S.A. - GENEVA; Intellectual Property 9, chemin des Mines CH-1202 Geneva, CH
Priority Data
07115408.231.08.2007EP
60/966,98931.08.2007US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS
(FR) COMPOSÉS DE TRIAZOLOPYRIDINE ET LEUR UTILISATION COMME INHIBITEURS DE ASK
Abstract
(EN)
The present invention relates to triazolopyridine compounds according to Formula (I), their use as medicament, for treating autoimmune disorders, inflammatorydiseases, cardiovascular disceases and/or neurodegenerative diseases and a process for their preparation.
(FR)
La présente invention porte sur des composés de triazolopyridine selon la formule (I), leur utilisation comme médicament pour le traitement de troubles auto-immuns, de maladies inflammatoires, de maladies cardio-vasculaires et/ou de maladies neurodégénératives, et sur un procédé permettant de les préparer.
Latest bibliographic data on file with the International Bureau