WO2009027283 TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS

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Publication Number WO/2009/027283

Publication Date 05.03.2009

International Application No. PCT/EP2008/060884

International Filing Date 20.08.2008

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Applicants

MERCK SERONO S.A. [CH]/[CH] (AllExceptUS)
SWINNEN, Dominique [BE]/[FR] (UsOnly)
JORAND-LEBRUN, Catherine [FR]/[FR] (UsOnly)
GRIPPI - VALLOTTON, Tania [CH]/[CH] (UsOnly)
MUZERELLE, Mathilde [FR]/[FR] (UsOnly)
ROYLE, Amanda [GB]/[GB] (UsOnly)
MACRITCHIE, Jacqueline [GB]/[GB] (UsOnly)
HILL, Richard [GB]/[GB] (UsOnly)
SHAW, Jeffrey P. [IT]/[CH] (UsOnly)

Inventors

SWINNEN, Dominique
JORAND-LEBRUN, Catherine
GRIPPI - VALLOTTON, Tania
MUZERELLE, Mathilde
ROYLE, Amanda
MACRITCHIE, Jacqueline
HILL, Richard
SHAW, Jeffrey P.

Agents

MERCK SERONO S.A. - GENEVA

Priority Data

07115408.2		31.08.2007		EP
60/966,989		31.08.2007		US

Publication Language English (en)

Filing Language English (EN)

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Title

(EN) TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS

(FR) COMPOSÉS DE TRIAZOLOPYRIDINE ET LEUR UTILISATION COMME INHIBITEURS DE ASK

Abstract

(EN) The present invention relates to triazolopyridine compounds according to Formula (I), their use as medicament, for treating autoimmune disorders, inflammatorydiseases, cardiovascular disceases and/or neurodegenerative diseases and a process for their preparation.

(FR) La présente invention porte sur des composés de triazolopyridine selon la formule (I), leur utilisation comme médicament pour le traitement de troubles auto-immuns, de maladies inflammatoires, de maladies cardio-vasculaires et/ou de maladies neurodégénératives, et sur un procédé permettant de les préparer.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
471	Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02	in which the condensed system contains two hetero rings
04	Ortho-condensed systems

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435	having six-membered rings with one nitrogen as the only ring hetero atom
4353	ortho- or peri-condensed with heterocyclic ring systems
437	the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29	Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
471	Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02	in which the condensed system contains two hetero rings
04	Ortho-condensed systems

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435	having six-membered rings with one nitrogen as the only ring hetero atom
4353	ortho- or peri-condensed with heterocyclic ring systems
437	the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline

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1. WO2009027283 - TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS