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1. WO2009027283 - TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS

Publication Number WO/2009/027283
Publication Date 05.03.2009
International Application No. PCT/EP2008/060884
International Filing Date 20.08.2008
IPC
C07D 471/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/437 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 29/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
CPC
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
A61P 37/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
06Immunosuppressants, e.g. drugs for graft rejection
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applicants
  • MERCK SERONO S.A. [CH]/[CH] (AllExceptUS)
  • SWINNEN, Dominique [BE]/[FR] (UsOnly)
  • JORAND-LEBRUN, Catherine [FR]/[FR] (UsOnly)
  • GRIPPI - VALLOTTON, Tania [CH]/[CH] (UsOnly)
  • MUZERELLE, Mathilde [FR]/[FR] (UsOnly)
  • ROYLE, Amanda [GB]/[GB] (UsOnly)
  • MACRITCHIE, Jacqueline [GB]/[GB] (UsOnly)
  • HILL, Richard [GB]/[GB] (UsOnly)
  • SHAW, Jeffrey P. [IT]/[CH] (UsOnly)
Inventors
  • SWINNEN, Dominique
  • JORAND-LEBRUN, Catherine
  • GRIPPI - VALLOTTON, Tania
  • MUZERELLE, Mathilde
  • ROYLE, Amanda
  • MACRITCHIE, Jacqueline
  • HILL, Richard
  • SHAW, Jeffrey P.
Agents
  • MERCK SERONO S.A. - GENEVA
Priority Data
07115408.231.08.2007EP
60/966,98931.08.2007US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS
(FR) COMPOSÉS DE TRIAZOLOPYRIDINE ET LEUR UTILISATION COMME INHIBITEURS DE ASK
Abstract
(EN) The present invention relates to triazolopyridine compounds according to Formula (I), their use as medicament, for treating autoimmune disorders, inflammatorydiseases, cardiovascular disceases and/or neurodegenerative diseases and a process for their preparation.
(FR) La présente invention porte sur des composés de triazolopyridine selon la formule (I), leur utilisation comme médicament pour le traitement de troubles auto-immuns, de maladies inflammatoires, de maladies cardio-vasculaires et/ou de maladies neurodégénératives, et sur un procédé permettant de les préparer.
Latest bibliographic data on file with the International Bureau