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1. (WO2009023549) VACCINE AGAINST BOTULISM
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2009/023549 International Application No.: PCT/US2008/072585
Publication Date: 19.02.2009 International Filing Date: 08.08.2008
IPC:
C12N 15/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
Applicants:
UNIVERSITY OF ROCHESTER [US/US]; 601 Elmwood Avenue, Box Oot Rochester, NY 14642, US (AllExceptUS)
ZENG, Mingtao [US/US]; US (UsOnly)
PICHICHERO, Michael, E. [US/US]; US (UsOnly)
XU, Qingfu [CN/US]; US (UsOnly)
Inventors:
ZENG, Mingtao; US
PICHICHERO, Michael, E.; US
XU, Qingfu; US
Agent:
MERKEL, Edwin, V.; Nixon Peabody Llp 1100 Clinton Square Rochester, NY 14604-1792, US
Priority Data:
60/954,92109.08.2007US
Title (EN) VACCINE AGAINST BOTULISM
(FR) VACCIN CONTRE LE BOTULISME
Abstract:
(EN) The invention relates to novel DNA and protein vaccines against Clostridium botulinum. The DNA vaccine includes a DNA molecule that includes a first segment encoding a fragment of a heavy chain region of a Clostridium botulinum neurotoxin, wherein the first segment is codon-enhanced to improve expression of the isolated DNA molecule in a mammalian host, and preferably a second segment that encodes a secretion signal peptide. The chimeric protein of the present invention includes the secretion signal peptide linked N-terminal of the fragment of a heavy chain region of a Clostridium botulinum neurotoxin. Use of these materials to raise antibodies, and to impart resistance against Clostridium botulinum to a mammal is also disclosed.
(FR) La présente invention concerne de nouveaux vaccins à ADN et protéiques contre Clostridium botulinum. Le vaccin à ADN comprend une molécule d'ADN qui comprend un premier segment codant pour un fragment d'une région de la chaîne lourde d'une neurotoxine Clostridium botulinum, où le premier segment est amplifié d'un codon pour améliorer l'expression d'une molécule d'ADN isolée chez un hôte mammifère, et de préférence un second segment qui code pour un peptide signal de sécrétion. La protéine chimère de la présente invention comprend l'extrémité N-terminale liée au peptide signal de sécrétion du fragment d'une région de la chaîne lourde d'une neurotoxine Clostridium botulinum. La présente invention décrit également l'utilisation de ces matériels pour provoquer des anticorps, et pour conférer une résistance contre Clostridium botulinum à un mammifère.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20120003241