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1. (WO2009020654) COMPOSITIONS AND METHODS FOR CRYSTALLIZING ANTIBODIES

Pub. No.:    WO/2009/020654    International Application No.:    PCT/US2008/009549
Publication Date: Fri Feb 13 00:59:59 CET 2009 International Filing Date: Sat Aug 09 01:59:59 CEST 2008
IPC: A61K 39/395
Applicants: ABBOTT LABORATORIES
FRAUNHOFER, Wolfgang
BORHANI, David W.
WINTER, Gerhard
GOTTSCHALK, Stefan
Inventors: FRAUNHOFER, Wolfgang
BORHANI, David W.
WINTER, Gerhard
GOTTSCHALK, Stefan
Title: COMPOSITIONS AND METHODS FOR CRYSTALLIZING ANTIBODIES
Abstract:
The present invention relates to a batch crystallization method for crystallizing anti-human TNFalpha (hTNFalpha) antibody and antibody fragments which allows the production of said antibody on an industrial scale; a method of controlling the size of antibody crystals, for example, crystals of anti-hTNFalpha antibody fragments, compositions containing said crystals as well as methods of use of said crystals and compositions.