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1. (WO2009017753) CHITOSAN-BASED BIOPOLYMER SYSTEM FOR TREATING DEGENERATIVE DISC DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2009/017753 International Application No.: PCT/US2008/009198
Publication Date: 05.02.2009 International Filing Date: 30.07.2008
IPC:
A61L 24/08 (2006.01) ,A61L 27/52 (2006.01) ,A61L 27/20 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24
Surgical adhesives or cements; Adhesives for colostomy devices
04
containing macromolecular materials
08
Polysaccharides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
50
Materials characterised by their function or physical properties
52
Hydrogels or hydrocolloids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
14
Macromolecular materials
20
Polysaccharides
Applicants:
ABRAHAMS, John, M. [US/US]; US (UsOnly)
CHEN, Weiliam [US/US]; US (UsOnly)
ZAHOS, Peter [US/US]; US (UsOnly)
ENDOMEDIX, INC. [US/US]; 12 Sulgrave Road Scarsdale, New York 10583, US (AllExceptUS)
Inventors:
ABRAHAMS, John, M.; US
CHEN, Weiliam; US
ZAHOS, Peter; US
Agent:
GOODWIN PROCTER LLP; Exchange Place Boston, MA 02109, US
Priority Data:
11/830,12530.07.2007US
Title (EN) CHITOSAN-BASED BIOPOLYMER SYSTEM FOR TREATING DEGENERATIVE DISC DISEASE
(FR) SYSTÈME DE BIOPOLYMÈRE POUR FERMETURE DE TISSU
Abstract:
(EN) The invention provides a method of treating degenerative disc disease and discogenic pain by disposing a hydrogel tissue sealant within the intervertebral disc, where the hydrogel fills voids and tears in the annulus fibrosus and replaces leaked material from the nucleus pulposus. The hydrogel is formed in situ from a substantially liquid premix, which can be emplaced with a syringe needle or a catheter into the intervertebral disc, where it forms the hydrogel by gelation. The hydrogel can also include a therapeutic or a protective material, or a radiopaque or MRI-active agent to aid in visualization.
(FR) L'invention porte sur un procédé de traitement d'une maladie dégénérative d'un disque et d'une douleur d'origine discale par le dépôt d'un agent de fermeture de tissu formant un hydrogel à l'intérieur du disque intervertébral, l'hydrogel remplissant les vides et les déchirures dans l'anneau fibreux périphérique du disque intervertébral et remplaçant une matière ayant fui du noyau pulpeux. L'hydrogel est formé in situ à partir d'un pré-mélange sensiblement liquide qui peut être placé avec une aiguille de seringue ou un cathéter dans le disque intervertébral où il forme l'hydrogel par gélification. L'hydrogel peut également comprendre une matière thérapeutique ou protectrice ou un agent radiopaque ou actif en IRM pour faciliter sa visualisation.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)