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1. (WO2009016142) 9-DEOXO-9A-METHYL-9A-AZA-9A-HOMOERYTHROMYCIN A DERIVATIVES AND THEIR USE FOR THE TREATMENT OF MALARIA
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2009/016142 International Application No.: PCT/EP2008/059848
Publication Date: 05.02.2009 International Filing Date: 28.07.2008
IPC:
C07H 17/00 (2006.01) ,A61K 31/7052 (2006.01) ,A61P 33/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17
Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7052
having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33
Antiparasitic agents
02
Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
06
Antimalarials
Applicants:
ALIHODZIC, Sulejman [HR/HR]; HR (UsOnly)
PERIC, Mihaela [HR/HR]; HR (UsOnly)
PESIC, Dijana [HR/HR]; HR (UsOnly)
GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. [HR/HR]; Prilaz baruna Filipovica 29 10000 Zagreb, HR (AllExceptUS)
Inventors:
ALIHODZIC, Sulejman; HR
PERIC, Mihaela; HR
PESIC, Dijana; HR
Agent:
CRAWLEY, Karen, A. ; GlaxoSmithKline Corporate Intellectual Property CN925.1 980 Great West Road Brentford Middlesex TW8 9GS, GB
Priority Data:
60/952,64930.07.2007US
Title (EN) 9-DEOXO-9A-METHYL-9A-AZA-9A-HOMOERYTHROMYCIN A DERIVATIVES AND THEIR USE FOR THE TREATMENT OF MALARIA
(FR) DÉRIVÉS DE 9-DÉSOXO-9A-MÉTHYL-9A-AZA-9A-HOMOÉRYTHROMYCINE A ET LEURS UTILISATIONS POUR LE TRAITEMENT DE LA MALARIA
Abstract:
(EN) The present invention relates to novel 2'-O-substituted 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin A derivatives having antimalarial activity. More particularly, the invention relates to 2'-O-substituted-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin A and 2'-O-substituted-3-O-decladinosyl-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin A derivatives having antimalarial activity, to the intermediates for their preparation, to the methods for their preparation, to their use as therapeutic agents, and to salts thereof having antimalarial activity.
(FR) La présente invention porte sur de nouveaux dérivés de 2'-O-substitué-9-désoxo-9a-méthyl-9a-aza-9a-homoérythromycine A, ayant une activité anti-malarienne. Plus particulièrement, l'invention porte sur les dérivés 2'-O-substitué-9-désoxo-9a-méthyl-9a-aza-9a-homoérythromycine A et 2'-O-substitué-3-O-décladinosyl-9-désoxo-9a-méthyl-9a-aza-9a-homoérythromycine A ayant une activité anti-malarienne, sur les intermédiaires permettant de les préparer, sur les procédés permettant de les préparer, sur leur utilisation comme agents thérapeutiques et sur leurs sels ayant une activité anti-malarienne.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)