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1. WO2009016142 - 9-DEOXO-9A-METHYL-9A-AZA-9A-HOMOERYTHROMYCIN A DERIVATIVES AND THEIR USE FOR THE TREATMENT OF MALARIA

Publication Number WO/2009/016142
Publication Date 05.02.2009
International Application No. PCT/EP2008/059848
International Filing Date 28.07.2008
IPC
C07H 17/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
A61K 31/7052 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
A61P 33/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33Antiparasitic agents
02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
06Antimalarials
CPC
A61P 33/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33Antiparasitic agents
02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
06Antimalarials
C07H 17/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
Y02A 50/30
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
50in human health protection, e.g. against extreme weather
30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applicants
  • GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. [HR]/[HR] (AllExceptUS)
  • ALIHODZIC, Sulejman [HR]/[HR] (UsOnly)
  • PERIC, Mihaela [HR]/[HR] (UsOnly)
  • PESIC, Dijana [HR]/[HR] (UsOnly)
Inventors
  • ALIHODZIC, Sulejman
  • PERIC, Mihaela
  • PESIC, Dijana
Agents
  • CRAWLEY, Karen, A.
Priority Data
60/952,64930.07.2007US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) 9-DEOXO-9A-METHYL-9A-AZA-9A-HOMOERYTHROMYCIN A DERIVATIVES AND THEIR USE FOR THE TREATMENT OF MALARIA
(FR) DÉRIVÉS DE 9-DÉSOXO-9A-MÉTHYL-9A-AZA-9A-HOMOÉRYTHROMYCINE A ET LEURS UTILISATIONS POUR LE TRAITEMENT DE LA MALARIA
Abstract
(EN) The present invention relates to novel 2'-O-substituted 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin A derivatives having antimalarial activity. More particularly, the invention relates to 2'-O-substituted-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin A and 2'-O-substituted-3-O-decladinosyl-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin A derivatives having antimalarial activity, to the intermediates for their preparation, to the methods for their preparation, to their use as therapeutic agents, and to salts thereof having antimalarial activity.
(FR) La présente invention porte sur de nouveaux dérivés de 2'-O-substitué-9-désoxo-9a-méthyl-9a-aza-9a-homoérythromycine A, ayant une activité anti-malarienne. Plus particulièrement, l'invention porte sur les dérivés 2'-O-substitué-9-désoxo-9a-méthyl-9a-aza-9a-homoérythromycine A et 2'-O-substitué-3-O-décladinosyl-9-désoxo-9a-méthyl-9a-aza-9a-homoérythromycine A ayant une activité anti-malarienne, sur les intermédiaires permettant de les préparer, sur les procédés permettant de les préparer, sur leur utilisation comme agents thérapeutiques et sur leurs sels ayant une activité anti-malarienne.
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