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1. WO2009016084 - SPIRO CYCLOPENTANE COMPOUNDS USEFUL AS ANTAGONISTS OF THE H1-RECEPTOR

Publication Number WO/2009/016084
Publication Date 05.02.2009
International Application No. PCT/EP2008/059682
International Filing Date 24.07.2008
IPC
C07C 211/38 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
211Compounds containing amino groups bound to a carbon skeleton
33having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
34of a saturated carbon skeleton
38containing condensed ring systems
A61K 31/131 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
131acyclic
A61P 25/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
CPC
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
20Hypnotics; Sedatives
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07C 211/38
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
211Compounds containing amino groups bound to a carbon skeleton
33having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
34of a saturated carbon skeleton
38containing condensed ring systems
C07C 2603/94
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2603Systems containing at least three condensed rings
93Spiro compounds
94containing "free" spiro atoms
Applicants
  • GLAXO GROUP LIMITED [GB]/[GB] (AllExceptUS)
  • CASTIGLIONI, Emiliano [IT]/[IT] (UsOnly)
  • DI FABIO, Romano [IT]/[IT] (UsOnly)
  • GIANOTTI, Massimo [IT]/[IT] (UsOnly)
  • MESIC, Milan [HR]/[HR] (UsOnly)
  • PAVONE, Francesca [IT]/[IT] (UsOnly)
  • RAST, Slavko [HR]/[HR] (UsOnly)
  • STASI, Luigi, Piero [IT]/[IT] (UsOnly)
Inventors
  • CASTIGLIONI, Emiliano
  • DI FABIO, Romano
  • GIANOTTI, Massimo
  • MESIC, Milan
  • PAVONE, Francesca
  • RAST, Slavko
  • STASI, Luigi, Piero
Agents
  • SEWELL, Richard, Charles
Priority Data
0714712.727.07.2007GB
0723318.228.11.2007GB
0806289.507.04.2008GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SPIRO CYCLOPENTANE COMPOUNDS USEFUL AS ANTAGONISTS OF THE H1-RECEPTOR
(FR) NOUVEAUX COMPOSÉS
Abstract
(EN) This invention relates to novel spiro cyclopentane derivatives of formula (I) or a pharmaceutically acceptable salt thereof, for treating diseases and conditions of the central nervous system (CNS), in particular sleep disorders.
(FR) La présente invention concerne de nouveaux dérivés spiro cyclopentane de formule (I) ou un sel pharmaceutiquement acceptable de ces derniers, utiles pour traiter les maladies et les troubles du système nerveux central (SNC), notamment les troubles du sommeil.
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