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1. WO2009015385 - ANTIMICROBIAL PEPTIDE, COMPOSITIONS, AND METHODS OF USE

Publication Number WO/2009/015385
Publication Date 29.01.2009
International Application No. PCT/US2008/071350
International Filing Date 28.07.2008
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
CPC
A61K 38/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
A61K 38/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61K 38/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 47/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen, ; e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
A61K 8/64
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
64Proteins; Peptides; Derivatives or degradation products thereof
A61K 9/0014
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0014Skin, i.e. galenical aspects of topical compositions
Applicants
  • REVANCE THERAPEUTICS, INC. [US]/[US] (AllExceptUS)
  • STONE, Hongran Fan [US]/[US] (UsOnly)
  • WAUGH, Jacob M. [US]/[US] (UsOnly)
Inventors
  • STONE, Hongran Fan
  • WAUGH, Jacob M.
Agents
  • ENG, Joseph, Jr.
Priority Data
60/952,05926.07.2007US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTIMICROBIAL PEPTIDE, COMPOSITIONS, AND METHODS OF USE
(FR) PEPTIDE ANTIMICROBIEN, COMPOSITIONS ET PROCÉDÉS D'UTILISATION
Abstract
(EN)
The present invention provides antimicrobial peptides that exhibit a broad range of antimicrobial activity to gram positive and gram negative bacteria, as well as fungi, mold, and virus. The antimicrobial peptide of the invention is a cationic peptide, and may contain an HIV-TAT or reverse HIV-TAT sequence, or derivative thereof. The present invention further provides antimicrobial compositions containing the cationic peptide. Such compositions are especially useful for topical application to the skin, hair, nail, vagina, urethra, ear, oral cavity, nasal passage, respiratory system, opthalmic region, and various mucosal regions. The compositions of the present invention improve the condition and/or appearance of the treated region, and are suited for long-term and/or routine use to, for example, prevent or prevent the recurrence of microbial infection. The present invention further provides kits for use in improving the condition or appearance of skin, nail, or treated area. These kits may facilitate ease of use, long-term storage, and/or efficacy of the compositions.
(FR)
La présente invention concerne des peptides antimicrobiens qui affichent une large gamme d'activités antimicrobiennes vis-à-vis de bactérie Gram-positif et Gram négatif, ainsi que des champignons, moisissures et virus. Le peptide antimicrobien de l'invention est un peptide cationique et peut contenir une séquence VIH-TAT ou VIH-TAT inverse, ou un dérivé de celles-ci. La présente invention concerne en outre des compositions antimicrobiennes contenant le peptide cationique. De telles compositions sont spécialement utiles pour une application topique à la peau, aux cheveux, aux ongles, au vagin, à l'urètre, aux oreilles, à la cavité orale, au passage nasal, au système respiratoire, à la région ophtalmique et à diverses régions de muqueuse. Les compositions de la présente invention améliorent la condition et/ou l'apparence de la région traitée, et sont appropriées pour une utilisation à long terme et/ou coutumière pour, par exemple, prévenir ou prévenir la récurrence d'une infection microbienne. La présente invention concerne en outre des nécessaires à utiliser dans l'amélioration de la condition de l'apparence de la peau, des ongles ou d'une zone traitée. Ces nécessaires peuvent faciliter l'utilisation, le stockage à long terme et/ou l'efficacité des compositions.
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