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1. (WO2009013724) TRIMETAL-ARENE CLUSTERS WITH ANTICANCER ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2009/013724 International Application No.: PCT/IB2008/052998
Publication Date: 29.01.2009 International Filing Date: 25.07.2008
IPC:
C07F 17/02 (2006.01) ,A61K 31/28 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
17
Metallocenes
02
of metals of the iron group or the platinum group
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
28
Compounds containing heavy metals
Applicants:
THERRIEN, Bruno [CA/CH]; CH (UsOnly)
SÜSS-FINK, Georg [DE/CH]; CH (UsOnly)
DYSON, Paul Joseph [GB/CH]; CH (UsOnly)
ANG, Wee Han [CN/US]; US (UsOnly)
Ecole Polytechnique Fédérale de Lausanne (EPFL) [CH/CH]; SRI-CM2 Station 10 CH-1015 Lausanne, CH (AllExceptUS)
Inventors:
THERRIEN, Bruno; CH
SÜSS-FINK, Georg; CH
DYSON, Paul Joseph; CH
ANG, Wee Han; US
Agent:
GANGUILLET, Cyril; ABREMA Agence Brevets et Marques, Ganguillet Avenue du Théâtre 16, CP 5027 CH-1002 Lausanne, CH
Priority Data:
07113278.126.07.2007EP
Title (EN) TRIMETAL-ARENE CLUSTERS WITH ANTICANCER ACTIVITY
(FR) AGRÉGATS DE TRIMÉTAL-ARÈNE AVEC ACTIVITÉ ANTICANCÉREUSE
Abstract:
(EN) The present invention relates to new medicaments, pharmaceutical compositions and methods of treatment of cancer. Disclosed are trimetallic clusters for use as a medicament, in particular in the treatment of cancer including metastasis. Preferably, the compounds are provided in the form of pharmaceutically acceptable salts. Preferred compound include trinuclear ruthenium- arene clusters as exemplified by the compounds 1a and 1b shown in Figure 1.
(FR) La présente invention concerne de nouveaux médicaments, compositions pharmaceutiques et procédés de traitement du cancer. L'invention concerne des agrégats trimétalliques pour une utilisation comme médicament, en particulier dans le traitement du cancer y compris de la métastase. De préférence, les composés sont fournis sous la forme de sels pharmaceutiquement acceptables. Les composés préférés comprennent des agrégats du ruthénium trinuclaire-arène selon les exemples des composés 1a et 1b montrés sur la figure 1.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)