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1. (WO2009012786) NANOPARTICLE-MEDIATED TREATMENT FOR INFLAMMATORY DISEASES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2009/012786 International Application No.: PCT/DK2008/050184
Publication Date: 29.01.2009 International Filing Date: 23.07.2008
Chapter 2 Demand Filed: 29.06.2009
IPC:
C12N 15/11 (2006.01) ,A61K 31/713 (2006.01) ,C12N 15/87 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
713
Double-stranded nucleic acids or oligonucleotides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
87
Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
Applicants:
AARHUS UNIVERSITET [DK/DK]; Nordre Ringgade 1 DK-8000 Århus C, DK (AllExceptUS)
KJEMS, Jørgen [DK/DK]; DK (UsOnly)
HOWARD, Kenneth Alan [GB/DK]; DK (UsOnly)
BESENBACHER, Flemming [DK/DK]; DK (UsOnly)
DELEURAN, Bent [DK/DK]; DK (UsOnly)
Inventors:
KJEMS, Jørgen; DK
HOWARD, Kenneth Alan; DK
BESENBACHER, Flemming; DK
DELEURAN, Bent; DK
Agent:
PLOUGMANN & VINGTOFT A/S; Sundkrogsgade 9 P.O. Box 831 DK-2100 Copenhagen Ø, DK
Priority Data:
PA 2007 0107923.07.2007DK
Title (EN) NANOPARTICLE-MEDIATED TREATMENT FOR INFLAMMATORY DISEASES
(FR) TRAITEMENT INDUIT PAR NANOPARTICULE DESTINÉ AUX MALADIES INFLAMMATOIRES
Abstract:
(EN) The present invention provides nanoparticles for treatment of inflammatory diseases. The nanoparticles preferably comprise chitosan and a siRNA targeting a mRNA encoding a pro-inflammatory cytokine, such as e.g. tnf-alfa. A preferred route of administration of the nanoparticles is by injection intraperitoneally.
(FR) La présente invention concerne des nanoparticules destinées au traitement de maladies inflammatoires. Lesdites nanoparticules comprennent de préférence du chitosane et un siRNA qui cible un mRNA codant pour une cytokine pro-inflammatoire, telle que tnf-alfa par exemple. L'une des voies d'administration préférée desdites nanoparticules est l'injection intrapéritonéale.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2176411US20100272813CA2731399