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1. WO2009010841 - CULTURE FOR EXPANDING STEM CELLS EX-VIVO

Publication Number WO/2009/010841
Publication Date 22.01.2009
International Application No. PCT/IB2008/001798
International Filing Date 09.07.2008
IPC
C12N 5/073 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
073Embryonic cells or tissues; Foetal cells or tissues
C12N 5/078 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
CPC
A61K 2035/124
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
124the cells being hematopoietic, bone marrow derived or blood cells
A61P 19/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
08for bone diseases, e.g. rachitism, Paget's disease
10for osteoporosis
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
A61P 37/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
A61P 7/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
06Antianaemics
Applicants
  • FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO [IT]/[IT] (AllExceptUS)
  • LAZZARI, Lorenza [IT]/[IT] (UsOnly)
  • MONTEMURRO, Tiziana [IT]/[IT] (UsOnly)
  • GIORDANO, Rosaria [IT]/[IT] (UsOnly)
  • REBULLA, Paolo [IT]/[IT] (UsOnly)
  • SIRCHIA, Girolamo [IT]/[IT] (UsOnly)
Inventors
  • LAZZARI, Lorenza
  • MONTEMURRO, Tiziana
  • GIORDANO, Rosaria
  • REBULLA, Paolo
  • SIRCHIA, Girolamo
Agents
  • BOTTERO, Carlo
Priority Data
MI2007A00142116.07.2007IT
Publication Language English (EN)
Filing Language Italian (IT)
Designated States
Title
(EN) CULTURE FOR EXPANDING STEM CELLS EX-VIVO
(FR) CULTURE D'EXPANSION DE CELLULES SOUCHES EX VIVO
Abstract
(EN)
The present invention relates to a culture including a growth medium and a combination of cytokines consisting of i) interleukin-6 (IL6); ii) flt3-ligand (FLT3); iii) stem cell factor (SCF) and iv) thrombopoi- etin (TPO); the use of the culture for expanding.ex vivo stem cells and/or parental cells and cells differentiated therefrom, and the use of said cells obtainable from said expansion.
(FR)
L'invention concerne une culture contenant un milieu de croissance et une combinaison de cytokines constituée i) d'interleukine-6 (IL6); ii) de ligand Flt3 (FLT3); iii) de facteur des cellules souches (FCS); et iv) de thrombopoïétine (TPO). L'invention concerne également l'utilisation de cette culture dans l'expansion ex vivo de cellules souches et/ou de cellules parentales et de cellules différenciées à partir de celles-ci, ainsi que l'utilisation des cellules obtenues à partir de cette expansion.
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