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1. WO2009009198 - SERS NANOTAG ASSAYS

Publication Number WO/2009/009198
Publication Date 15.01.2009
International Application No. PCT/US2008/060871
International Filing Date 18.04.2008
IPC
G01J 3/00 2006.01
GPHYSICS
01MEASURING; TESTING
JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3Spectrometry; Spectrophotometry; Monochromators; Measuring colours
CPC
B01J 2219/00572
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
0054Means for coding or tagging the apparatus or the reagents
00572Chemical means
B01J 2219/00576
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
0054Means for coding or tagging the apparatus or the reagents
00572Chemical means
00576fluorophore
B01J 2219/00722
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00718Type of compounds synthesised
0072Organic compounds
00722Nucleotides
B01J 2219/00725
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00718Type of compounds synthesised
0072Organic compounds
00725Peptides
B82Y 20/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
20Nanooptics, e.g. quantum optics or photonic crystals
B82Y 30/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
30Nanotechnology for materials or surface science, e.g. nanocomposites
Applicants
  • BECTON, DICKINSON AND COMPANY [US]/[US] (AllExceptUS)
  • NATAN, Michael J. [US]/[US]
Inventors
  • NATAN, Michael J.
Agents
  • BECTON, DICKINSON AND COMPANY
Priority Data
60/912,59918.04.2007US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SERS NANOTAG ASSAYS
(FR) BIO-ESSAIS UTILISANT DES NANO-MARQUEURS SERS
Abstract
(EN)
A method of producing a surface enhanced Raman scattering spectrum which is useful for certain types of assays, in particular proximity assays. The method includes providing two SERS-active nanoparticles. The first SERS-active nanoparticle will absorb a photon at a first wavelength and emit a Raman-shifted photon at a second wavelength. The second SERS-active nanoparticle will absorb a photon at the second wavelength and emit a Raman-shifted photon at a third wavelength. Accordingly, when the first and second SERS-active nanoparticles are proximate to one another and the first SERS-active nanoparticle is illuminated at the first wavelength a Raman-shifted photon at the second wavelength may be emitted. This photon can be absorbed by the second SERS-active nanoparticle causing detectable emission of a second Raman-shifted photon at the third wavelength. Various assays may be designed based upon the above. Proximity assays using two SERS-active nanoparticles will have advantageous background signal characteristics.
(FR)
L'invention concerne un procédé pour produire un spectre de diffusion de Raman amélioré en surface qui est utile pour certains types de bio-essais, en particulier des bio-essais de proximité. Le procédé comprend la fourniture de deux nanoparticules actives de SERS. La première nanoparticule active de SERS va absorber un photon à une première longueur d'onde, et émettre un photon à décalage de Raman à une seconde longueur d'onde. La seconde nanoparticule active de SERS va absorber un photon à la deuxième longueur d'onde, et émettre un photon à décalage de Raman à une troisième longueur d'onde. En conséquence, lorsque les première et seconde nanoparticules actives de SERS sont à proximité l'une de l'autre, et lorsque la première nanoparticule active de SERS est éclairée à la première longueur d'onde, un photon à décalage de Raman à la deuxième longueur d'onde peut être émis. Ce photon peut être absorbé par la seconde nanoparticule active de SERS, en provoquant une émission pouvant être détectée d'un second photon à décalage de Raman à la troisième longueur d'onde. Divers bio-essais peuvent être conçus sur la base de ce qui précède. Des bio-essais de proximité utilisant deux nanoparticules actives de SERS vont avoir des caractéristiques de signal de fond avantageuses.
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