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1. WO2009009117 - CHEMOENZYMATIC PROCESSES FOR PREPARATION OF LEVETIRACETAM

Publication Number WO/2009/009117
Publication Date 15.01.2009
International Application No. PCT/US2008/008503
International Filing Date 11.07.2008
IPC
C12P 17/10 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms
10Nitrogen as only ring hetero atom
C12P 41/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
41Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
C12N 9/88 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
88Lyases (4.)
CPC
C12N 9/88
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
88Lyases (4.)
C12P 17/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
10Nitrogen as only ring hetero atom
C12P 41/006
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
41Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
006by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
C12Y 402/01084
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
YENZYMES
402Carbon-oxygen lyases (4.2)
01Hydro-lyases (4.2.1)
01084Nitrile hydratase (4.2.1.84)
Applicants
  • BIOVERDANT, INC. [US]/[US] (AllExceptUS)
  • TUCKER, John, Lloyd [US]/[US] (UsOnly)
  • XU, Lan [CN]/[US] (UsOnly)
  • YU, Weihong [US]/[US] (UsOnly)
  • SCOTT, Robert, William [US]/[US] (UsOnly)
  • ZHAO, Lishan [CN]/[US] (UsOnly)
  • RAN, Ningqing [CN]/[US] (UsOnly)
Inventors
  • TUCKER, John, Lloyd
  • XU, Lan
  • YU, Weihong
  • SCOTT, Robert, William
  • ZHAO, Lishan
  • RAN, Ningqing
Agents
  • SEIDMAN, Stephanie, L.
Priority Data
60/959,20911.07.2007US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CHEMOENZYMATIC PROCESSES FOR PREPARATION OF LEVETIRACETAM
(FR) PROCÉDÉS CHIMIO-ENZYMATIQUE POUR LA PRÉPARATION DU LÉVÉTIRACÉTAM
Abstract
(EN)
Compounds and processes for preparing intermediates in the synthesis of levetiracetam and precursors of levetiracetam and related compounds are provided. Also provided are processes for the preparation of levetiracetam or a pharmaceutically acceptable salt thereof. Modified nitrile hydratase polypeptides and uses thereof also are provided. Among the modified nitrile hydratase polypeptides provided are those that have altered activities, including altered enantioselectivity.
(FR)
L'invention concerne des composés et des procédés de préparation de produits intermédiaires dans la synthèse du lévétiracétam et de précurseurs du lévétiracétam et de composés associés. Des procédés de préparation du lévétiracétam ou d'un sel pharmaceutiquement acceptable de celui-ci sont également fournis. Des polypeptides modifiés de nitrilhydratase et leurs utilisations sont également fournis. Parmi les polypeptides modifiés de nitrilhydratase fournis, on trouve ceux dont les activités sont modifiées, y compris une énantiosélectivité modifiée.
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