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1. WO2009007724 - DIAGNOSIS AND TREATMENT OF ABNORMAL BLOOD CONDITIONS

Publication Number WO/2009/007724
Publication Date 15.01.2009
International Application No. PCT/GB2008/002364
International Filing Date 10.07.2008
IPC
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/136
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
136Screening for pharmacological compounds
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
Applicants
  • EUROPEAN CARDIOVASCULAR GENETICS FOUNDATION [GB]/[GB] (AllExceptUS)
  • OUWEHAND, Willem [NL]/[GB] (UsOnly)
  • GOODALL, Alison, Helena [GB]/[GB] (UsOnly)
Inventors
  • OUWEHAND, Willem
  • GOODALL, Alison, Helena
Agents
  • THORNTON, Neil
Priority Data
0713363.010.07.2007GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DIAGNOSIS AND TREATMENT OF ABNORMAL BLOOD CONDITIONS
(FR) DIAGNOSTIC ET TRAITEMENT D'ÉTATS ANORMAUX DU SANG
Abstract
(EN)
Methods for diagnosing whether a subject has, or is at risk of, an abnormal blood condition are described. The methods comprise determining the expression level of a gene specifically associated with adenosine-di-phosphate (ADP)-stimulated platelet activation, collagen-related peptide (CRP)-stimulated platelet activation, or ADP- and CRP-stimulated platelet activation in a biological sample obtained from the subject. Methods for identifying potential therapeutic agents for the treatment of abnormal blood conditions are also described.
(FR)
L'invention porte sur des procédés pour diagnostiquer si un sujet a ou présente un risque de présenter, un état anormal du sang. Les procédés comprennent la détermination du niveau d'expression d'un gène associé de façon spécifique à une activation de plaquettes stimulée par l'adénosine-di-phosphate (ADP), une activation de plaquettes stimulée par le peptide apparenté au collagène (CRP) ou une activation de plaquettes stimulée par l'ADP et le CRP dans un échantillon biologique obtenu à partir du sujet. L'invention porte également sur des procédés pour identifier des agents thérapeutiques potentiels pour le traitement d'états anormaux du sang.
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