WO2009006959 PYRIDAZINONE DERIVATES

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Publication Number WO/2009/006959

Publication Date 15.01.2009

International Application No. PCT/EP2008/003473

International Filing Date 29.04.2008

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Applicants

MERCK PATENT GMBH [DE]/[DE] (AllExceptUS)
DORSCH, Dieter [DE]/[DE] (UsOnly)
STIEBER, Frank [DE]/[DE] (UsOnly)
SCHADT, Oliver [DE]/[DE] (UsOnly)
BLAUKAT, Andree [DE]/[DE] (UsOnly)

Inventors

DORSCH, Dieter
STIEBER, Frank
SCHADT, Oliver
BLAUKAT, Andree

Common Representative

MERCK PATENT GMBH

Priority Data

10 2007 032 507.1

12.07.2007

Publication Language German (de)

Filing Language German (DE)

Designated States

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Title

(DE) PYRIDAZINONDERIVATE

(EN) PYRIDAZINONE DERIVATES

(FR) DÉRIVÉS DE PYRIDAZINONE

Abstract

(DE) Verbindungen der Formel (I) worin R¹, R², R³, R⁴, R^4' die in Anspruch (1) angegebenen Bedeutungen haben, sind Inhibitoren der Tyrosinkinasen, insbesondere der Met-Kinase und können u.a. zur Behandlung von Tumoren eingesetzt werden.

(EN) Compounds of the formula (I) in which R¹, R², R³, R⁴, R^4' are each as defined in claim (1) are inhibitors of tyrosine kinases, especially of Met kinase, and can be used, inter alia, for treatment of tumours.

(FR) L'invention concerne des composés de formule (I), dans laquelle R¹, R², R³, R⁴, R^4' ont les significations données dans la revendication (1), lesdits composés étant des inhibiteurs des tyrosines kinases, notamment de la kinase MET et pouvant être utilisés entre autres pour le traitement de tumeurs.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
403	Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14	containing three or more hetero rings

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
413	Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02	containing two hetero rings
10	linked by a carbon chain containing aromatic rings

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
417	Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02	containing two hetero rings
10	linked by a carbon chain containing aromatic rings

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
413	Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14	containing three or more hetero rings

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
403	Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14	containing three or more hetero rings

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1. WO2009006959 - PYRIDAZINONE DERIVATES

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495	having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
50	Pyridazines; Hydrogenated pyridazines
501	not condensed and containing further heterocyclic rings

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1	Drugs for disorders of the alimentary tract or the digestive system
16	for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
0012	Galenical forms characterised by the site of application
0014	Skin, i.e. galenical aspects of topical compositions

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
0012	Galenical forms characterised by the site of application
0019	Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
14	Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
19	lyophilised ; , i.e. freeze-dried, solutions or dispersions

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
20	Pills, tablets, ; discs, rods
2004	Excipients; Inactive ingredients
2013	Organic compounds, e.g. phospholipids, fats
2018	Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates