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1. WO2009006860 - A METHOD OF MANUFACTURING 4'-[[4-METHYL-6-(1-METHYL-1H-BENZIMIDAZOL-2-YL)-2-PROPYL-1H-BENZIMIDAZOL-1YL]METHYL]BIPHENYL-2-CARBOXYLIC ACID (TELMISARTAN)

Publication Number WO/2009/006860
Publication Date 15.01.2009
International Application No. PCT/CZ2008/000080
International Filing Date 08.07.2008
IPC
C07D 235/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
235Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
02condensed with carbocyclic rings or ring systems
04Benzimidazoles; Hydrogenated benzimidazoles
18with aryl radicals directly attached in position 2
CPC
C07D 235/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
235Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
02condensed with carbocyclic rings or ring systems
04Benzimidazoles; Hydrogenated benzimidazoles
06with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
14Radicals substituted by nitrogen atoms
Applicants
  • ZENTIVA A.S. [CZ]/[CZ] (AllExceptUS)
  • STACH, Jan [CZ]/[CZ] (UsOnly)
  • RADL, Stanislav [CZ]/[CZ] (UsOnly)
  • CINIBULK, Josef [CZ]/[CZ] (UsOnly)
  • STRELEC, Ivo [CZ]/[CZ] (UsOnly)
  • JARRAH, Kamal [CZ]/[CZ] (UsOnly)
Inventors
  • STACH, Jan
  • RADL, Stanislav
  • CINIBULK, Josef
  • STRELEC, Ivo
  • JARRAH, Kamal
Agents
  • JIROTKOVA, Ivana
Priority Data
PV 2007-45709.07.2007CZ
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A METHOD OF MANUFACTURING 4'-[[4-METHYL-6-(1-METHYL-1H-BENZIMIDAZOL-2-YL)-2-PROPYL-1H-BENZIMIDAZOL-1YL]METHYL]BIPHENYL-2-CARBOXYLIC ACID (TELMISARTAN)
(FR) PROCÉDÉ DE FABRICATION D'ACIDE 4'-[[4-MÉTHYL-6-(1-MÉTHYL-1H-BENZIMIDAZOL-2-YL)-2-PROPYL-1H-BENZIMIDAZOL-1-YL]MÉTHYL]BIPHENYL-2-CARBOXYLIQUE (TELMISARTAN)
Abstract
(EN)
A carboxylic acid of the general formula R1COOH, wherein R1 is the hydrogen atom or a C1-C4 alkyl, is added to a solution of the potassium salt of telmisartan in an alcohol of the formula R2OH with the water content lower than 2%, wherein R2 is ethyl or methyl.
(FR)
L'invention concerne un procédé de fabrication de telmisartan consistant à ajouter un acide carboxylique de formule générale R1COOH, dans laquelle formule R1 est un atome d'hydrogène ou un alkyle en C1-C4, à une solution du sel de potassium de telmisartan dans un alcool de formule R2OH ayant une teneur en eau inférieure à 2 %, dans laquelle formule R2 est un éthyle ou un méthyle.
Also published as
UAa201001360
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