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1. (WO2009006404) HETEROCYCLIC COMPOUNDS USEFUL AS RAF KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/006404    International Application No.:    PCT/US2008/068789
Publication Date: 08.01.2009 International Filing Date: 30.06.2008
IPC:
C07D 413/12 (2006.01), C07D 413/14 (2006.01), C07D 417/12 (2006.01), C07D 417/14 (2006.01), A61P 35/00 (2006.01), A61K 31/505 (2006.01)
Applicants: SUNESIS PHARMACEUTICALS, INC. [US/US]; 395 Oyster Point Boulevard, Suite 400 South San Francisco, CA 94080 (US) (For All Designated States Except US).
BIOGEN IDEC MA INC. [--/US]; 14 Cambridge Center Cambridge, MA 02142 (US) (For All Designated States Except US).
COSSROW, Jennifer [US/US]; (US) (For US Only).
GUAN, Bing [US/US]; (US) (For US Only).
ISHCHENKO, Alexey [UA/US]; (US) (For US Only).
JONES, John, Howard [CA/US]; (US) (For US Only).
KUMARAVEL, Gnanasambandam [US/US]; (US) (For US Only).
LUGOVSKOY, Alexey [RU/US]; (US) (For US Only).
PENG, Hairuo [CN/US]; (US) (For US Only).
POWELL, Noel [US/US]; (US) (For US Only).
RAIMUNDO, Brian [US/US]; (US) (For US Only).
TANAKA, Hiroko [JP/US]; (US) (For US Only).
VESSELS, Jeffrey [US/US]; (US) (For US Only).
WYNN, Thomas [US/US]; (US) (For US Only).
XIN, Zhili [US/US]; (US) (For US Only)
Inventors: COSSROW, Jennifer; (US).
GUAN, Bing; (US).
ISHCHENKO, Alexey; (US).
JONES, John, Howard; (US).
KUMARAVEL, Gnanasambandam; (US).
LUGOVSKOY, Alexey; (US).
PENG, Hairuo; (US).
POWELL, Noel; (US).
RAIMUNDO, Brian; (US).
TANAKA, Hiroko; (US).
VESSELS, Jeffrey; (US).
WYNN, Thomas; (US).
XIN, Zhili; (US)
Agent: ROBIDOUX, Andrea, L.C.; Choate, Hall & Stewart LLP Two International Place Boston, MA 02110 (US)
Priority Data:
60/947,319 29.06.2007 US
Title (EN) HETEROCYCLIC COMPOUNDS USEFUL AS RAF KINASE INHIBITORS
(FR) COMPOSÉS HÉTÉROCYCLIQUES UTILES EN TANT QU'INHIBITEURS DE LA KINASE RAF
Abstract: front page image
(EN)The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Cy1 is an optionally substituted phenyl or an optionally substituted 5-6 membered saturated, partially unsaturated, or aromatic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; Cy2 is an optionally substituted 5-10 membered saturated, partially unsaturated, or aromatic monocyclic or bicyclic ring having 0-4 heteroatoms, independently selected from nitrogen, oxygen, or sulfur; L1 is a direct bond of an optionally substituted, straight or branched C1-6 alkylene chain; L2 is a direct bond, or is an optionally substituted, straight or branched C1-6 alkylene chain wherein 1 or 2 methylene units of L2 are optionally and independently replaced by -O-, -S-, -N(R)-, -C(O)-, -C(O)N(R)-, -N(R)C(O)N(R)-, -N(R)C(O)-, -N(R)C(O)O-, -OC(O)N(R)-, -SO2-, -SO2N(R)-, -N(R)SO2-, -OC(O)-, -C(O)O-, or a 3-6 membered cycloalkylene; each R is independently hydrogen or an optionally substituted C1-6 aliphatic group;
(FR)La présente invention porte sur des composés utiles en tant qu'inhibiteurs de la protéine kinase Raf. La présente invention porte également sur les compositions de ceux-ci, et sur des procédés de traitement des maladies à médiation par Raf.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)