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1. WO2009006338 - ANALYSIS OF AMINO ACIDS IN BODY FLUID BY LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY

Publication Number WO/2009/006338
Publication Date 08.01.2009
International Application No. PCT/US2008/068653
International Filing Date 27.06.2008
IPC
G01N 33/00 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
CPC
G01N 30/7233
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography ; or field flow fractionation;
02Column chromatography
62Detectors specially adapted therefor
72Mass spectrometers
7233interfaced to liquid or supercritical fluid chromatograph
G01N 33/6806
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6803General methods of protein analysis not limited to specific proteins or families of proteins
6806Determination of free amino acids
G01N 33/6809
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6803General methods of protein analysis not limited to specific proteins or families of proteins
6806Determination of free amino acids
6809involving fluorescent derivatizing reagents reacting non-specifically with all amino acids
G01N 33/6848
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6803General methods of protein analysis not limited to specific proteins or families of proteins
6848Methods of protein analysis involving mass spectrometry
H01J 49/00
HELECTRICITY
01BASIC ELECTRIC ELEMENTS
JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
49Particle spectrometers or separator tubes
Applicants
  • QUEST DIAGNOSTICS INVESTMENTS INCORPORATED [US]/[US] (AllExceptUS)
  • GOLDMAN, Scott [US]/[US] (UsOnly)
Inventors
  • GOLDMAN, Scott
Agents
  • WILSON, Barry
Priority Data
60/947,33829.06.2007US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANALYSIS OF AMINO ACIDS IN BODY FLUID BY LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY
(FR) ANALYSE D'ACIDES AMINÉS DANS UN LIQUIDE CORPOREL PAR SPECTROMÉTRIE DE MASSE-CHROMATOGRAPHIE EN PHASE LIQUIDE
Abstract
(EN)
This disclosure provides methods for quantifying individual amino acids in various bodily fluids obtained from a human patient. Also provided are reference ranges for normal amino acid levels in the various bodily fluids (e.g., blood plasma, urine, cerebrospinal fluid, and saliva) and for various age groups (e.g., neonates, infants, children, and adults).
(FR)
Cette invention porte sur des procédés pour quantifier des acides aminés individuels dans divers liquides corporels obtenus à partir d'un patient humain. L'invention concerne également des plages de référence pour des niveaux d'acide aminé normaux dans divers liquides corporels (par exemple, le plasma sanguin, l'urine, le liquide cérébro-spinal et la salive) et pour divers groupes d'âges (par exemple, des nouveau-nés, des enfants en bas âge, des enfants et des adultes).
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