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1. WO2009006130 - SALT FREE HYALURONATE OPHTHALMIC SOLUTION

Publication Number WO/2009/006130
Publication Date 08.01.2009
International Application No. PCT/US2008/068090
International Filing Date 25.06.2008
Chapter 2 Demand Filed 21.04.2009
IPC
A61K 9/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
08Solutions
A61K 31/535 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
A61K 31/195 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
A61K 31/155 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
155Amidines , e.g. guanidine , isourea , isothiourea
CPC
A61K 31/155
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
A61K 31/195
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
A61K 31/535
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
A61K 9/0048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0048Eye, e.g. artificial tears
Applicants
  • BAUSCH & LOMB INCORPORATED [US]/[US] (AllExceptUS)
  • VENKATESH, Srini [US]/[US] (UsOnly)
  • XIA, Erning [US]/[US] (UsOnly)
Inventors
  • VENKATESH, Srini
  • XIA, Erning
Agents
  • SMITH, Glenn, D.
Priority Data
60/946,80128.06.2007US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SALT FREE HYALURONATE OPHTHALMIC SOLUTION
(FR) SOLUTION OPHTALMIQUE À BASE D'HYALURONATE EXEMPTE DE SEL
Abstract
(EN)
The present invention is directed to an ophthalmic composition in the form of a topical aqueous solution consisting essentially of an ophthalmologically active agent, an ion sensitive, hydrophilic polymer in an amount a of 0.004 to 1.5% by weight, at least one salt selected from the group of inorganic salts and buffers in a total amount of from 0.01 to 2.0% by weight, a wetting agent in an amount of 0 to 3.0% by weight, a preservative in an amount of 0 to 0.02% by weight, water, and optionally a pH regulating agent in an amount sufficient to give a pH of 4.0 to 8.0 to the composition, the ratio between salt and polymer components being such that the solution exhibits a viscosity of less than 1000 mPas. The composition contains a sufficient amount of polymer to provide for a controlled absorption of the drug into the eye, its viscosity having been reduced to provide for better handling characteristics.
(FR)
La présente invention porte sur une composition ophtalmique sous la forme d'une solution aqueuse topique consistant essentiellement en un agent ophtalmologiquement actif, un ion sensible, un polymère hydrophile dans une quantité a de 0,004 à 1,5 % en poids, au moins un sel choisi dans le groupe constitué par des sels inorganiques et des tampons dans une quantité totale d'environ 0,01 à 2,0 % en poids, un agent mouillant dans une quantité de 0 à 3,0 % en poids, un conservateur dans une quantité de 0 à 0,02 % en poids, de l'eau et facultativement un agent de régulation du pH dans une quantité suffisante pour donner un pH de 4,0 à 8,0 à la composition, le rapport entre les composants de sel et polymère étant tel que la solution présente une viscosité de moins de 1 000 mPas. La composition contient une quantité suffisante de polymère pour fournir une absorption contrôlée du médicament dans l'œil, sa viscosité ayant été réduite pour fournir de meilleures caractéristiques de manipulation.
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