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1. WO2009004146 - NOVEL HERBIMYCIN A ANALOGUE DERIVATIVES, COMPOSITIONS CONTAINING SAME AND USE THEREOF

Publication Number WO/2009/004146
Publication Date 08.01.2009
International Application No. PCT/FR2008/000709
International Filing Date 23.05.2008
IPC
C07D 225/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
225Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
04condensed with carbocyclic rings or ring systems
06condensed with one six-membered ring
A61K 31/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 21/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 27/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 33/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33Antiparasitic agents
Applicants
  • SANOFI-AVENTIS [FR]/[FR] (AllExceptUS)
  • BELLOSTA, Véronique [FR]/[FR] (UsOnly)
  • BIGOT, Antony [FR]/[FR] (UsOnly)
  • CANOVA, Sophie [FR]/[FR] (UsOnly)
  • COSSY, Janine [FR]/[FR] (UsOnly)
  • MAILLIET, Patrick [FR]/[FR] (UsOnly)
  • MIGNANI, Serge [FR]/[FR] (UsOnly)
  • MINOUX, Hervé [FR]/[FR] (UsOnly)
Inventors
  • BELLOSTA, Véronique
  • BIGOT, Antony
  • CANOVA, Sophie
  • COSSY, Janine
  • MAILLIET, Patrick
  • MIGNANI, Serge
  • MINOUX, Hervé
Agents
  • BOURGOUIN-MULLER, Alessandra
Priority Data
070367324.05.2007FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) NOVEL HERBIMYCIN A ANALOGUE DERIVATIVES, COMPOSITIONS CONTAINING SAME AND USE THEREOF
(FR) NOUVEAUX DÉRIVES ANALOGUES DE L'HERBIMYCINE A, COMPOSITIONS LES CONTENANT ET UTILISATION
Abstract
(EN)
The invention relates to products having formula (I), in which A represents one of the following three rings: ring a, ring b, ring c and W represents hydrogen or -(C1-C4)alkyl, -(C1-C4)alkenyl, -CO-(C1-C3)alkyl, - CO-(C1-C3)alkenyl, -CO-NH-(C1-C2)alkyl, -CO-NH-(C1-C2)alkenyl or -CO-NH2, carbon C15 having stereochemical configuration R or S and the double bond between carbons C4 and C5 having geometry E or Z, providing that W does not represent hydrogen or methyl when A represents ring b and carbon C15 has stereochemical configuration R. The invention relates to all of the isomeric forms of the products and the salts thereof for use as drugs.
(FR)
Produits de formule (I), avec A représente l'un des trois cycles suivants: cycle a, cycle b, cycle c et W représente hydrogène ou -(C1-C4)alkyle, -(C1 -C4)alkényle, -CO-(C1 -C3)alkyle, - CO-(C1-C3)alkényle, -CO-NH-(C1 -C2)alkyle, -CO-NH-(C1 -C2)alkényle ou -CO-NH2; le carbone C15 ayant la configuration stéréochimique R ou S, et la double liaison entre les carbones C4 et C5 ayant une géométrie E ou Z, étant entendu que lorsque A représente le cycle b et le carbone C15 a la configuration stéréochimique R alors W ne représente pas hydrogène ou méthyle, ces produits étant sous toutes les formes isomères et les sels, à titre de médicaments.
Also published as
Latest bibliographic data on file with the International Bureau