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1. WO2009003255 - PHARMACEUTICAL COMPOSITIONS COMPRISING SEMICARBAZONES AND THIOSEMICAR-BAZONES AND METHOD FOR TREATING INFLAMMATORY, PAINFUL AND FEBRILE CONDITIONS AND PREVENTING SIGNS AND SYMPTOMS

Publication Number WO/2009/003255
Publication Date 08.01.2009
International Application No. PCT/BR2008/000023
International Filing Date 25.01.2008
IPC
A61K 31/175 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
17having the group N-C(O)-N or N-C(S)-N, e.g. urea, thiourea, carmustine
175having the group , N-C(O)-N=N- or , e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
A61P 23/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
23Anaesthetics
A61P 25/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
CPC
A61K 31/175
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
17having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
175having the group , >N—C(O)—N=N— or , e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
A61K 31/724
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
716Glucans
724Cyclodextrins
A61K 47/6951
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
6949inclusion complexes, e.g. clathrates, cavitates or fullerenes
6951using cyclodextrin
A61K 49/0008
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
0004Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
0008Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
A61K 9/0019
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
A61P 23/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
23Anaesthetics
Applicants
  • UNIVERSIDADE FEDERAL DE MINAS GERAIS [BR]/[BR] (AllExceptUS)
  • DE OLIVEIRA BERALDO, Heloisa [BR]/[BR] (UsOnly)
  • DE MATOS COELHO, Márcio [BR]/[BR] (UsOnly)
  • DARIO SINISTERRA, Ruben [CO]/[BR] (UsOnly)
  • DORETTO, Maria Carolina [BR]/[BR] (UsOnly)
  • PINTO VIEIRA, Rafael [BR]/[BR] (UsOnly)
  • DE SOUZA TEIXEIRA, Letícia Regina [BR]/[BR] (UsOnly)
  • PASSOS ANDRADE, Silvia [BR]/[BR] (UsOnly)
Inventors
  • DE OLIVEIRA BERALDO, Heloisa
  • DE MATOS COELHO, Márcio
  • DARIO SINISTERRA, Ruben
  • DORETTO, Maria Carolina
  • PINTO VIEIRA, Rafael
  • DE SOUZA TEIXEIRA, Letícia Regina
  • PASSOS ANDRADE, Silvia
Agents
  • DANNEMANN, SIEMSEN, BIGLER & IPANEMA MOREIRA
Priority Data
C10200751-702.07.2007BR
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PHARMACEUTICAL COMPOSITIONS COMPRISING SEMICARBAZONES AND THIOSEMICAR-BAZONES AND METHOD FOR TREATING INFLAMMATORY, PAINFUL AND FEBRILE CONDITIONS AND PREVENTING SIGNS AND SYMPTOMS
(FR) COMPOSITIONS PHARMACEUTIQUES COMPRENANT DES SEMICARBAZONES ET DES THIOSEMICARBAZONES ET PROCÉDÉ POUR TRAITER DES ÉTATS INFLAMMATOIRES, DOULOUREUX ET FÉBRILES ET PRÉVENIR DES SIGNES ET DES SYMPTÔMES
Abstract
(EN)
The present patent application refers to pharmaceutical compositions comprising at least a semicarbazone or a thiosemicarbazone, or a pharmaceutically acceptable salt, hydrated or solvated thereof, for the treatment of inflammatory, febrile and painful inflammatory conditions, inflammatory edema and peripheral or central neurophatic painful conditions or prevention of signs and symptoms of inflammation. Claim also pharmaceutical compositions comprising at least a semicarbazone, or a thiosemicarbazone, or a pharmaceutically acceptable salt, hydrated or solvated thereof and a therapeutically effective amount of these compounds, mixed or included in a pharmaceutically acceptable carrier or excipient or a thiosemicarbazone is provided as sustained or controlled release systems for human and veterinary use in solutions or in the solid state.
(FR)
La présente invention porte sur des compositions pharmaceutiques comprenant au moins une semicarbazone ou une thiosemicarbazone, ou un sel pharmaceutiquement acceptable, hydraté ou solvaté, de celles-ci, pour le traitement d'états inflammatoires, fébriles et inflammatoires douloureux, d'un œdème inflammatoire ou d'états de douleur neuropathique périphérique ou centrale ou la prévention de signes et de symptômes d'une inflammation. L'invention porte également sur des compositions pharmaceutiques comprenant au moins une semicarbazone, ou une thiosemicarbazone, ou un sel pharmaceutiquement acceptable, hydraté ou solvaté, de celles-ci et une quantité thérapeutiquement efficace de ces composés, mélangés ou compris dans un véhicule ou excipient pharmaceutiquement acceptable, ou une thiosemicarbazone, en tant que systèmes à libération prolongée ou contrôlée pour une utilisation médicale humaine et vétérinaire dans des solutions ou à l'état solide.
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