PATENTSCOPE will be unavailable a few hours for maintenance reason on Monday 03.02.2020 at 10:00 AM CET
Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2009000087) SUBSTITUTED FUSED PYRIMIDINES AS ANTAGONISTS OF GPR105 ACTIVITY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2009/000087 International Application No.: PCT/CA2008/001214
Publication Date: 31.12.2008 International Filing Date: 26.06.2008
IPC:
C07D 471/04 (2006.01) ,A61K 31/519 (2006.01) ,A61P 3/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
Applicants:
MERCK FROSST CANADA LTD. [CA/CA]; 16711 Trans-Canada Highway Kirkland, Québec H9H 3L1, CA (AllExceptUS)
GUAY, Daniel [CA/CA]; CA (UsOnly)
BEAULIEU, Christian [CA/CA]; CA (UsOnly)
BELLEY, Michel [CA/CA]; CA (UsOnly)
CRANE, Sheldon, N. [CA/CA]; CA (UsOnly)
DE LUCA, Jeancarlo [CA/CA]; CA (UsOnly)
FORTIN, Rejean [CA/CA]; CA (UsOnly)
GAREAU, Yves [CA/CA]; CA (UsOnly)
LI, Lianhai [CA/CA]; CA (UsOnly)
THERIEN, Michel [CA/CA]; CA (UsOnly)
TRANMER, Geoffrey, K. [CA/CA]; CA (UsOnly)
TRUONG, Vouy, Linh [CA/CA]; CA (UsOnly)
WANG, Zhaoyin [CA/CA]; CA (UsOnly)
Inventors:
GUAY, Daniel; CA
BEAULIEU, Christian; CA
BELLEY, Michel; CA
CRANE, Sheldon, N.; CA
DE LUCA, Jeancarlo; CA
FORTIN, Rejean; CA
GAREAU, Yves; CA
LI, Lianhai; CA
THERIEN, Michel; CA
TRANMER, Geoffrey, K.; CA
TRUONG, Vouy, Linh; CA
WANG, Zhaoyin; CA
Agent:
OGILVY RENAULT LLP/S.E.N.C.R.L., S.R.L.; Bureau 2500 1, Place Ville Marie Montréal, Québec H3B 1R1, CA
Priority Data:
60/937,79228.06.2007US
Title (EN) SUBSTITUTED FUSED PYRIMIDINES AS ANTAGONISTS OF GPR105 ACTIVITY
(FR) PYRIMIDINES FUSIONNÉES SUBSTITUÉES EN TANT QU'ANTAGONISTES DE L'ACTIVITÉ DE GPR105
Abstract:
(EN) Fused pyrimidine compounds of structural formula (I) are effective as antagonists of the biological activity of the GPR105 protein. They are useful for the treatment, control or prevention of disorders responsive to antagonism of this receptor, such as diabetes, particularly, Type 2 diabetes, insulin resistance, hyperglycemia, lipid disorders, obesity, atherosclerosis, and Metabolic Syndrome.
(FR) L'invention concerne des composés de pyrimidine fusionnée de formule structurale (I) qui sont efficaces comme antagonistes de l'activité biologique de la protéine GPR105. Ils sont utiles pour le traitement, le contrôle ou la prévention d'affections qui répondent à un antagonisme de ce récepteur, telles que le diabète, en particulier le diabète type 2, la résistance à l'insuline, l'hyperglycémie, les troubles lipidiques, l'obésité, l'athérosclérose et le syndrome métabolique.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2170883JP2010531307US20100179173CA2691010AU2008267724