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1. (WO2008157752) SPIROCYCLES AS INHIBITORS OF 11-BETA HYDROXYL STEROID DEHYDROGENASE TYPE 1
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2008/157752 International Application No.: PCT/US2008/067637
Publication Date: 24.12.2008 International Filing Date: 20.06.2008
IPC:
C07D 471/10 (2006.01) ,A61K 31/444 (2006.01) ,A61P 3/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
10
Spiro-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
444
containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
04
Anorexiants; Antiobesity agents
Applicants:
YAO, Wenqing [US/US]; US (UsOnly)
ZHUO, Jincong [US/US]; US (UsOnly)
ZHANG, Colin [CN/US]; US (UsOnly)
INCYTE CORPORATION [US/US]; Experimental Station Route 141 & Henry Clay Road Building E336 Wilmington, Delaware 19880, US (AllExceptUS)
Inventors:
YAO, Wenqing; US
ZHUO, Jincong; US
ZHANG, Colin; US
Agent:
GODDARD, Christine A.; Fish & Richardson P.C. PO Box 1022 Minneapolis, Minnesota 55440-1022, US
Priority Data:
60/945,48721.06.2007US
Title (EN) SPIROCYCLES AS INHIBITORS OF 11-BETA HYDROXYL STEROID DEHYDROGENASE TYPE 1
(FR) SPIROCYCLES UTILISÉS EN TANT QU'INHIBITEURS DE LA 11-&Bgr;-HYDROXY-STÉROÏDE DÉSHYDROGÉNASE DE TYPE 1
Abstract:
(EN) The present invention relates to certain spirocyclic compounds that are inhibitors of 11- hydroxyl steroid dehydrogenase type 1 (11 HSD1), compositions containing the same, and methods of using the same for the treatment of diabetes, obesity and other diseases.
(FR) La présente invention concerne certains composés spirocycliques qui sont des inhibiteurs de la 11-β-hydroxy-stéroïde déshydrogénase de type 1 (11 HSD1), des compositions les contenant et des procédés les utilisant pour le traitement du diabète, de l'obésité et d'autres maladies.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)