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1. WO2008157179 - N-SUBSTITUTED AZAINDOLES AND METHODS OF USE

Publication Number WO/2008/157179
Publication Date 24.12.2008
International Application No. PCT/US2008/066570
International Filing Date 11.06.2008
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
C07D 471/04 (2006.01)
A61K 31/437 (2006.01)
A61P 35/00 (2006.01)
A61P 37/00 (2006.01)
CPC
C07D 471/04
Applicants
  • GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080, US (AllExceptUS)
  • DYKE, Hazel Joan [GB/GB]; GB (UsOnly)
  • PRICE, Stephen [GB/GB]; GB (UsOnly)
  • WILLIAMS, Karen [GB/GB]; GB (UsOnly)
Inventors
  • DYKE, Hazel Joan; GB
  • PRICE, Stephen; GB
  • WILLIAMS, Karen; GB
Agents
  • WANG, Min ; Genentech, Inc. 1 DNA Way, MS-49 South San Francisco, California 94080, US
Priority Data
60/943,44112.06.2007US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) N-SUBSTITUTED AZAINDOLES AND METHODS OF USE
(FR) AZAINDOLES N-SUBSTITUÉS ET PROCÉDÉS D'UTILISATION
Abstract
(EN)
The invention relates to N-substituted azaindolyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to N-substituted azaindolyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
(FR)
L'invention concerne des composés d'azaindolyle N-substitués de la formule I ayant une activité anticancéreuse et/ou anti-inflammatoire et plus spécifiquement des composés d'azaindolyle N-substitués qui empêchent une activité de la kinase MEK. L'invention fournit des compositions et des procédés utiles pour empêcher la croissance anormale d'une cellule ou traiter des troubles hyperprolifératifs, ou traiter une maladie inflammatoire chez un mammifère. L'invention concerne également des procédés d'utilisation des composés pour un diagnostic ou un traitement de cellules de mammifère in vitro, in situ, et in vivo, ou des conditions pathologiques associées.
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