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1. WO2008152387 - QUINAZOLINE DERIVATIVES AS PI3 KINASE INHIBITORS

Publication Number WO/2008/152387
Publication Date 18.12.2008
International Application No. PCT/GB2008/002009
International Filing Date 12.06.2008
IPC
C07D 413/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
A61K 31/5377 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
53751,4-Oxazines, e.g. morpholine
5377not condensed and containing further heterocyclic rings, e.g. timolol
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 31/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
CPC
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
C07D 413/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
Applicants
  • F.HOFFMANN-LA ROCHE AG [CH]/[CH] (AllExceptUS)
  • BAKER, Stewart, J. [GB]/[GB] (UsOnly)
  • HANCOX, Timothy, Colin [GB]/[GB] (UsOnly)
  • PEGG, Neil, Anthony [GB]/[GB] (UsOnly)
  • NADIN, Alan, John [GB]/[GB] (UsOnly)
  • PRICE, Stephen [GB]/[GB] (UsOnly)
Inventors
  • BAKER, Stewart, J.
  • HANCOX, Timothy, Colin
  • PEGG, Neil, Anthony
  • NADIN, Alan, John
  • PRICE, Stephen
Agents
  • KEEN, Celia, Mary
Priority Data
0711345.912.06.2007GB
0715676.310.08.2007GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) QUINAZOLINE DERIVATIVES AS PI3 KINASE INHIBITORS
(FR) DÉRIVÉS DE QUINAZOLINE COMME INHIBITEURS DE PI3 KINASE
Abstract
(EN) The invention provides a compound which is a quinazoline of formula (I): and the pharmaceutically acceptable salts thereof are inhibitors of PI3K and are selective for the p110δ isoform, which is a class Ia PI3 kinase, over other class Ia PI3 kinases and over class Ib kinases. The compounds may be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.
(FR) L'invention concerne un composé qui est une quinazoline de formule (I): et ses sels pharmaceutiquement acceptables qui sont des inhibiteurs de PI3K et sont sélectifs pour l'isoforme p110δ, qui est une kinase PI3 de classe Ia, par rapport à d'autres kinases PI3 de classe Ia et aux kinases de classe Ib. Les composés peuvent être utilisés pour traiter des maladies et des troubles provenant d'une croissance, d'une fonction ou d'un comportement cellulaire anormal, associé à une kinase PI3, comme le cancer, les troubles immunitaires, les maladies cardiovasculaires, les infections virales, les inflammations, les troubles de la fonction métabolique/endocrine et les troubles neurologiques.
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