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1. (WO2008151089) FLUORESCENT PHOSPHOLIPASE A2 INDICATORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2008/151089 International Application No.: PCT/US2008/065432
Publication Date: 11.12.2008 International Filing Date: 30.05.2008
IPC:
C12Q 1/34 (2006.01) ,G01N 33/573 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
34
involving hydrolase
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
573
for enzymes or isoenzymes
Applicants:
INVITROGEN CORPORATION [US/US]; 5791 Van Allen Way Carlsbad, California 92008, US (AllExceptUS)
KANG, Hee Chol [US/US]; US (UsOnly)
Inventors:
KANG, Hee Chol; US
Agent:
ANDERSON, Koren; Invitrogen Corporation c/o Intellevate P.O.Box 52050 Minneapolis, Minnesota 97402-9165, US
Priority Data:
60/940,79930.05.2007US
Title (EN) FLUORESCENT PHOSPHOLIPASE A2 INDICATORS
(FR) INDICATEURS FLUORESCENTS DE LA PHOSPHOLIPASE A2
Abstract:
(EN) Compositions, methods of synthesis and applications of phospholipase A2 (PLA2) specific enzyme substrates which exhibit fluorescence resonance energy transfer (FRET) are described. The compounds generally have the structure: (I) wherein, the variables are described throughout the application. These novel compounds provide a sensitive method to monitor real time PLA2 specific enzyme activities in various cells, tissues and small organisms with fluorescence-ratiometric analysis.
(FR) La présente invention concerne des compositions, des procédés de synthèse et des applications de substrats d'enzyme spécifiques de la phospholipase A2 (PLA2) qui présentent un transfert d'énergie entre deux molécules fluorescentes (Fluorescence Resonance Energy Transfer : FRET). Les composés ont la structure générale suivante : (I) dont les variables sont décrites dans l'ensemble de la demande. Ces composés innovants fournissent un procédé sensible permettant de suivre en temps réel les activités enzymatiques spécifiques de la PLA2 dans des cellules, des tissus et des petits organismes divers par une analyse des rapports de fluorescence.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20100203564