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1. WO2008149053 - BICYCL0 [2. 2. 1] HE PT- 2-YLAMINE DERIVATES AND THEIR USE

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Publication Number WO/2008/149053
Publication Date 11.12.2008
International Application No. PCT/GB2007/002130
International Filing Date 08.06.2007
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
211
Compounds containing amino groups bound to a carbon skeleton
33
having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
34
of a saturated carbon skeleton
38
containing condensed ring systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
211
Compounds containing amino groups bound to a carbon skeleton
62
Quaternary ammonium compounds
63
having quaternised nitrogen atoms bound to acyclic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
311
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02
ortho- or peri-condensed with carbocyclic rings or ring systems
78
Ring systems having three or more relevant rings
80
Dibenzopyrans; Hydrogenated dibenzopyrans
82
Xanthenes
84
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
311
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02
ortho- or peri-condensed with carbocyclic rings or ring systems
78
Ring systems having three or more relevant rings
80
Dibenzopyrans; Hydrogenated dibenzopyrans
82
Xanthenes
84
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
86
Oxygen atoms, e.g. xanthones
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
333
Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
02
not condensed with other rings
04
not substituted on the ring sulfur atom
06
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
24
Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
215
of carboxylic acids
216
of acids having aromatic rings, e.g. benactizyne, clofibrate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
352
condensed with carbocyclic rings, e.g. cannabinols, methantheline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
38
having sulfur as a ring hetero atom
381
having five-membered rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13
Drugs for disorders of the urinary system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
C07C 211/38 (2006.01)
C07C 211/63 (2006.01)
C07D 311/84 (2006.01)
C07D 311/86 (2006.01)
C07D 333/24 (2006.01)
C07D 409/12 (2006.01)
CPC
C07C 219/24
C07C 2601/14
C07C 2602/42
C07C 2603/18
C07D 311/82
C07D 333/24
Applicants
  • ARGENTA DISCOVERY LTD. [GB/GB]; 8/9 Spire Green Centre Flex Meadow Harlow Essex CM19 5TR, GB (AllExceptUS)
  • ASTRAZENECA AB [SE/SE]; S-151 85 S-SWEDEN Sodertalje, SE (AllExceptUS)
  • FINCH, Harry [GB/GB]; GB (UsOnly)
  • JENNINGS, Andrew, Stephan, Robert [GB/GB]; GB (UsOnly)
  • van NIEL, Monique, Bodil [NL/GB]; GB (UsOnly)
  • RAY, Nicholas, Charles [GB/GB]; GB (UsOnly)
  • SMITH, Philip [GB/GB]; GB (UsOnly)
Inventors
  • FINCH, Harry; GB
  • JENNINGS, Andrew, Stephan, Robert; GB
  • van NIEL, Monique, Bodil; GB
  • RAY, Nicholas, Charles; GB
  • SMITH, Philip; GB
Agents
  • MERCER, Christopher, Paul ; Carpmaels & Ransford 43-45 Bloomsbury Square London WC1A 2RA, GB
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BICYCL0 [2. 2. 1] HE PT- 2-YLAMINE DERIVATES AND THEIR USE
(FR) DÉRIVÉS DE LA BICYCLO[2.2.1]HEPT-2-YLAMINE ET LEUR UTILISATION
front page image
Abstract
(EN)
A named compound of formula (I): having M3 receptor antagonist activity; a composition comprising such a compound; the use of such a compound in therapy (such as asthma or COPD); and a method of treating a patient with such a compound.
(FR)
La présente invention concerne un composé nommé de formule (I) : ayant une activité antagoniste du récepteur M3 ; une composition comprenant un tel composé ; l'utilisation d'un tel composé en thérapie (telle que pour l'asthme ou la bronchopneumopathie chronique obstructive) ; et un procédé de traitement d'un patient avec un tel composé.
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