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1. WO2008149053 - BICYCL0 [2. 2. 1] HE PT- 2-YLAMINE DERIVATES AND THEIR USE

Publication Number WO/2008/149053
Publication Date 11.12.2008
International Application No. PCT/GB2007/002130
International Filing Date 08.06.2007
IPC
C07C 211/38 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
211Compounds containing amino groups bound to a carbon skeleton
33having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
34of a saturated carbon skeleton
38containing condensed ring systems
C07C 211/63 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
211Compounds containing amino groups bound to a carbon skeleton
62Quaternary ammonium compounds
63having quaternised nitrogen atoms bound to acyclic carbon atoms
C07D 311/84 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
78Ring systems having three or more relevant rings
80Dibenzopyrans; Hydrogenated dibenzopyrans
82Xanthenes
84with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
C07D 311/86 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
78Ring systems having three or more relevant rings
80Dibenzopyrans; Hydrogenated dibenzopyrans
82Xanthenes
84with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
86Oxygen atoms, e.g. xanthones
C07D 333/24 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
333Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
02not condensed with other rings
04not substituted on the ring sulfur atom
06with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D 409/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 13/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
C07C 219/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
219Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
24having esterified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
Applicants
  • ARGENTA DISCOVERY LTD. [GB]/[GB] (AllExceptUS)
  • ASTRAZENECA AB [SE]/[SE] (AllExceptUS)
  • FINCH, Harry [GB]/[GB] (UsOnly)
  • JENNINGS, Andrew, Stephan, Robert [GB]/[GB] (UsOnly)
  • van NIEL, Monique, Bodil [NL]/[GB] (UsOnly)
  • RAY, Nicholas, Charles [GB]/[GB] (UsOnly)
  • SMITH, Philip [GB]/[GB] (UsOnly)
Inventors
  • FINCH, Harry
  • JENNINGS, Andrew, Stephan, Robert
  • van NIEL, Monique, Bodil
  • RAY, Nicholas, Charles
  • SMITH, Philip
Agents
  • MERCER, Christopher, Paul
Priority Data
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) BICYCL0 [2. 2. 1] HE PT- 2-YLAMINE DERIVATES AND THEIR USE
(FR) DÉRIVÉS DE LA BICYCLO[2.2.1]HEPT-2-YLAMINE ET LEUR UTILISATION
Abstract
(EN) A named compound of formula (I): having M3 receptor antagonist activity; a composition comprising such a compound; the use of such a compound in therapy (such as asthma or COPD); and a method of treating a patient with such a compound.
(FR) La présente invention concerne un composé nommé de formule (I) : ayant une activité antagoniste du récepteur M3 ; une composition comprenant un tel composé ; l'utilisation d'un tel composé en thérapie (telle que pour l'asthme ou la bronchopneumopathie chronique obstructive) ; et un procédé de traitement d'un patient avec un tel composé.
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