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1. (WO2008142384) USE OF 4-(PYRROLIDIN-1-YL)QUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2008/142384 International Application No.: PCT/GB2008/001694
Publication Date: 27.11.2008 International Filing Date: 16.05.2008
IPC:
A61K 31/4709 (2006.01) ,A61K 31/517 (2006.01) ,A61P 31/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
4709
Non-condensed quinolines containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517
ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
Applicants:
BESWICK, Mandy, Christine [GB/GB]; GB (UsOnly)
CRAMP, Susan, Mary [GB/GB]; GB (UsOnly)
HU, Yanmin [GB/GB]; GB (UsOnly)
PALLIN, Thomas, David [GB/GB]; GB (UsOnly)
DYKE, Hazel, Joan [GB/GB]; GB (UsOnly)
COATES, Anthony [GB/GB]; GB (UsOnly)
HELPERBY THERAPEUTICS LIMITED [GB/GB]; 20/24 Park Street Selby North Yorks YO8 4PW, GB (AllExceptUS)
Inventors:
BESWICK, Mandy, Christine; GB
CRAMP, Susan, Mary; GB
HU, Yanmin; GB
PALLIN, Thomas, David; GB
DYKE, Hazel, Joan; GB
COATES, Anthony; GB
Agent:
NASCHEN, Neil; D. Young & Co. 120 Holborn London EC1N 2DY, GB
Priority Data:
0709489.917.05.2007GB
0807591.325.04.2008GB
Title (EN) USE OF 4-(PYRROLIDIN-1-YL)QUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS
(FR) UTILISATION DE COMPOSÉS DE 4-(PYRROLIDINE-1-YL)QUINOLÉINE POUR TUER DES MICRO-ORGANISMES CLINIQUEMENT LATENTS
Abstract:
(EN) There is provided the use of compounds of formula wherein R1, R2, R3 and E have meanings given in the description, for the preparation of a medicament for killing clinically latent microorganisms. There is also provided the use of compounds of formula I for treating microbial infections, as well as certain compounds of formula (I) per se.
(FR) L'invention propose l'utilisation de composés de la formule dans laquelle R1, R2, R3 et E ont les significations données dans la description, pour la préparation d'un médicament pour tuer des micro-organismes cliniquement latents. L'invention propose également l'utilisation de composés de formule I pour traiter des infections microbiennes, ainsi que certains composés de formule I per se.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)