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1. WO2008142384 - USE OF 4-(PYRROLIDIN-1-YL)QUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS

Publication Number WO/2008/142384
Publication Date 27.11.2008
International Application No. PCT/GB2008/001694
International Filing Date 16.05.2008
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
4709
Non-condensed quinolines containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517
ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
A61K 31/4709 (2006.01)
A61K 31/517 (2006.01)
A61P 31/04 (2006.01)
CPC
A61K 31/4709
A61K 31/497
A61K 31/501
A61K 31/517
C07D 401/04
C07D 403/14
Applicants
  • HELPERBY THERAPEUTICS LIMITED [GB/GB]; 20/24 Park Street Selby North Yorks YO8 4PW, GB (AllExceptUS)
  • BESWICK, Mandy, Christine [GB/GB]; GB (UsOnly)
  • CRAMP, Susan, Mary [GB/GB]; GB (UsOnly)
  • HU, Yanmin [GB/GB]; GB (UsOnly)
  • PALLIN, Thomas, David [GB/GB]; GB (UsOnly)
  • DYKE, Hazel, Joan [GB/GB]; GB (UsOnly)
  • COATES, Anthony [GB/GB]; GB (UsOnly)
Inventors
  • BESWICK, Mandy, Christine; GB
  • CRAMP, Susan, Mary; GB
  • HU, Yanmin; GB
  • PALLIN, Thomas, David; GB
  • DYKE, Hazel, Joan; GB
  • COATES, Anthony; GB
Agents
  • NASCHEN, Neil; D. Young & Co. 120 Holborn London EC1N 2DY, GB
Priority Data
0709489.917.05.2007GB
0807591.325.04.2008GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) USE OF 4-(PYRROLIDIN-1-YL)QUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS
(FR) UTILISATION DE COMPOSÉS DE 4-(PYRROLIDINE-1-YL)QUINOLÉINE POUR TUER DES MICRO-ORGANISMES CLINIQUEMENT LATENTS
Abstract
(EN)
There is provided the use of compounds of formula wherein R1, R2, R3 and E have meanings given in the description, for the preparation of a medicament for killing clinically latent microorganisms. There is also provided the use of compounds of formula I for treating microbial infections, as well as certain compounds of formula (I) per se.
(FR)
L'invention propose l'utilisation de composés de la formule dans laquelle R1, R2, R3 et E ont les significations données dans la description, pour la préparation d'un médicament pour tuer des micro-organismes cliniquement latents. L'invention propose également l'utilisation de composés de formule I pour traiter des infections microbiennes, ainsi que certains composés de formule I per se.
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