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1. (WO2008140586) MODULATION OF RHAMM (CD168) FOR SELECTIVE ADIPOSE TISSUE DEVELOPMENT
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2008/140586 International Application No.: PCT/US2007/085453
Publication Date: 20.11.2008 International Filing Date: 21.11.2007
IPC:
A61K 38/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
Applicants:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 12th Floor Oakland, CA 94607-5200, US (AllExceptUS)
LAWSON HEALTH RESEARCH INSTITUTE [CA/CA]; Victoria Hospital 790 Commissioner's Road East Victoria, ON N6A4L6, CA (AllExceptUS)
TURLEY, Eva, A. [CA/CA]; CA (UsOnly)
BISSELL, Mina, J. [US/US]; US (UsOnly)
Inventors:
TURLEY, Eva, A.; CA
BISSELL, Mina, J.; US
Agent:
WONG, Michelle Chew ; Lawrence Berkeley National Laboratory Technology Transfer And Ip Management Dept.- Patent Group, 1 Cyclotron Road, MS 90B0104 Berkeley, CA 94720-8127, US
Priority Data:
60/860,60621.11.2006US
60/860,60721.11.2006US
Title (EN) MODULATION OF RHAMM (CD168) FOR SELECTIVE ADIPOSE TISSUE DEVELOPMENT
(FR) MODULATION DE RHAMM (CD168) POUR UN DÉVELOPPEMENT SÉLECTIF DES TISSUS ADIPEUX
Abstract:
(EN) Herein is described the methods and compositions for modulation of Rhamm, also known as CD 186, and its effects on wound repair, muscle differentiation, bone density and adipogeneisis through its ability to regulate mesenchymal stem cell differentiation. Compositions and methods are provided for blocking Rhamm function for selectively increasing subcutaneous, but not, visceral fat. Compositions and methods for modulating Rhamm in wound repair are also described.
(FR) L'invention concerne des méthodes et des compositions de modulation de Rhamm, également connu sous le nom de CD 186, et ses effets sur la cicatrisation des plaies, la différenciation musculaire, la densité osseuse et l'adipogenèse grâce à sa capacité de régulation de la différenciation des cellules souches mésenchymateuses. L'invention concerne des compositions et des méthodes de blocage de la fonction de Rhamm pour augmenter de manière sélective la graisse sous-cutanée mais non viscérale. L'invention concerne également des compositions et des méthodes de modulation de Rhamm dans la cicatrisation des plaies.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)