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1. WO2008138842 - IMIDAZOPYRAZINES AND TRIAZOLOPYRAZINE FOR THE TREATMENT OF JOINT DEGENERATIVE AND INFLAMMATORY DISEASES

Publication Number WO/2008/138842
Publication Date 20.11.2008
International Application No. PCT/EP2008/055650
International Filing Date 07.05.2008
IPC
C07D 209/46 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
44Iso-indoles; Hydrogenated iso-indoles
46with an oxygen atom in position 1
C07D 487/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/4985 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A61P 29/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
CPC
A61P 1/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
Applicants
  • GALAPAGOS N.V. [BE]/[BE] (AllExceptUS)
  • ANDREWS, Martin, James, Inglis [GB]/[BE] (UsOnly)
  • CHAMBERS, Mark, Stuart [GB]/[GB] (UsOnly)
  • SCHMIDT, Wolfgang [DE]/[GB] (UsOnly)
  • CLASE, Juha, Andrew [GB]/[GB] (UsOnly)
  • BAR, Grégory, Louis, Joseph [FR]/[BE] (UsOnly)
  • TRICARICO, Giovanni, Alessandro [IT]/[BE] (UsOnly)
  • HIRST, Kim, Louise [GB]/[GB] (UsOnly)
  • ROUSSEL, Olga, Raquel, Pinto, Santos, Oliveira [PT]/[GB] (UsOnly)
Inventors
  • ANDREWS, Martin, James, Inglis
  • CHAMBERS, Mark, Stuart
  • SCHMIDT, Wolfgang
  • CLASE, Juha, Andrew
  • BAR, Grégory, Louis, Joseph
  • TRICARICO, Giovanni, Alessandro
  • HIRST, Kim, Louise
  • ROUSSEL, Olga, Raquel, Pinto, Santos, Oliveira
Agents
  • NICHOL, Maria
Priority Data
60/928,60010.05.2007US
60/931,76425.05.2007US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) IMIDAZOPYRAZINES AND TRIAZOLOPYRAZINE FOR THE TREATMENT OF JOINT DEGENERATIVE AND INFLAMMATORY DISEASES
(FR) IMIDAZOPYRAZINES ET TRIAZOLOPYRAZINES POUR LE TRAITEMENT DE MALADIES DÉGÉNÉRATIVES ET INFLAMMATOIRES DES ARTICULATIONS
Abstract
(EN) Novel fused pyrazine compounds are disclosed that have a formula represented by the following: formula (I), The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.
(FR) L'invention concerne de nouveaux composés de pyrazine fusionnée qui sont représentés par la formule (I). Les composés peuvent être préparés sous la forme de compositions pharmaceutiques et peuvent être utilisés pour la prévention et le traitement d'une diversité d'états chez les mammifères, y compris les êtres humains, comprenant, à titre d'exemple non limitatif, l'inflammation, la polyarthrite rhumatoïde et autres maladies.
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