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1. WO2008138842 - IMIDAZOPYRAZINES AND TRIAZOLOPYRAZINE FOR THE TREATMENT OF JOINT DEGENERATIVE AND INFLAMMATORY DISEASES

Publication Number WO/2008/138842
Publication Date 20.11.2008
International Application No. PCT/EP2008/055650
International Filing Date 07.05.2008
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
44
Iso-indoles; Hydrogenated iso-indoles
46
with an oxygen atom in position 1
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985
Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
C07D 209/46 (2006.01)
C07D 487/04 (2006.01)
A61K 31/4985 (2006.01)
A61P 29/00 (2006.01)
CPC
C07D 487/04
Applicants
  • GALAPAGOS N.V. [BE/BE]; Generaal De Wittelaan L11/A3 B-2800 Mechelen, BE (AllExceptUS)
  • ANDREWS, Martin, James, Inglis [GB/BE]; BE (UsOnly)
  • CHAMBERS, Mark, Stuart [GB/GB]; GB (UsOnly)
  • SCHMIDT, Wolfgang [DE/GB]; GB (UsOnly)
  • CLASE, Juha, Andrew [GB/GB]; GB (UsOnly)
  • BAR, Grégory, Louis, Joseph [FR/BE]; BE (UsOnly)
  • TRICARICO, Giovanni, Alessandro [IT/BE]; BE (UsOnly)
  • HIRST, Kim, Louise [GB/GB]; GB (UsOnly)
  • ROUSSEL, Olga, Raquel, Pinto, Santos, Oliveira [PT/GB]; GB (UsOnly)
Inventors
  • ANDREWS, Martin, James, Inglis; BE
  • CHAMBERS, Mark, Stuart; GB
  • SCHMIDT, Wolfgang; GB
  • CLASE, Juha, Andrew; GB
  • BAR, Grégory, Louis, Joseph; BE
  • TRICARICO, Giovanni, Alessandro; BE
  • HIRST, Kim, Louise; GB
  • ROUSSEL, Olga, Raquel, Pinto, Santos, Oliveira; GB
Agents
  • NICHOL, Maria; Galapagos NV Chesterford Research Park Little Chesterford Saffron Walden Essex CB10 1XL, GB
Priority Data
60/928,60010.05.2007US
60/931,76425.05.2007US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IMIDAZOPYRAZINES AND TRIAZOLOPYRAZINE FOR THE TREATMENT OF JOINT DEGENERATIVE AND INFLAMMATORY DISEASES
(FR) IMIDAZOPYRAZINES ET TRIAZOLOPYRAZINES POUR LE TRAITEMENT DE MALADIES DÉGÉNÉRATIVES ET INFLAMMATOIRES DES ARTICULATIONS
Abstract
(EN)
Novel fused pyrazine compounds are disclosed that have a formula represented by the following: formula (I), The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.
(FR)
L'invention concerne de nouveaux composés de pyrazine fusionnée qui sont représentés par la formule (I). Les composés peuvent être préparés sous la forme de compositions pharmaceutiques et peuvent être utilisés pour la prévention et le traitement d'une diversité d'états chez les mammifères, y compris les êtres humains, comprenant, à titre d'exemple non limitatif, l'inflammation, la polyarthrite rhumatoïde et autres maladies.
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