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1. (WO2008133866) POLYMORPH OF DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVE AS WEEL KINASE.INHIBITOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/133866    International Application No.:    PCT/US2008/005155
Publication Date: 06.11.2008 International Filing Date: 22.04.2008
IPC:
C07D 487/04 (2006.01), A61P 35/00 (2006.01), A61K 31/519 (2006.01)
Applicants: MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue, Rahway, New Jersey 07065-0907 (US) (For All Designated States Except US).
BANYU PHARMACEUTICAL CO., LTD. [JP/JP]; Kitanomaru Square, 1-13-12, Kudankita, Chiyoda-ku, Tokyo 102-8667 (JP) (For All Designated States Except US).
KAWASAKI, Masashi [JP/JP]; (JP) (For US Only).
MIZUNO, Hiroo [JP/JP]; (JP) (For US Only).
SAKAMOTO, Toshihiro [JP/JP]; (JP) (For US Only).
SUZUKI, Kimimasa [JP/JP]; (JP) (For US Only).
MCKEOWN, Arlene, E. [GB/US]; (US) (For US Only)
Inventors: KAWASAKI, Masashi; (JP).
MIZUNO, Hiroo; (JP).
SAKAMOTO, Toshihiro; (JP).
SUZUKI, Kimimasa; (JP).
MCKEOWN, Arlene, E.; (US)
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue, Rahway, New Jersey 07065-0907 (US)
Priority Data:
2007-115448 25.04.2007 JP
61/000,185 24.10.2007 US
Title (EN) POLYMORPH OF DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVE AS WEEL KINASE.INHIBITOR
(FR) POLYMORPHE DE DÉRIVÉ DE DIHYDROPYRAZOLOPYRIMIDINONE COMME INHIBITEUR DE LA KINASE WEEL
Abstract: front page image
(EN)The present invention relates to the crystalline forms of 2-allyl-l -[6-(I -hydroxy- 1 methylethyl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-l-yl)phenyl]amino}-l,2-dihydro-3H- pyrazolo[3,4-d]pyrirnidin-3-one or a salt thereof, which are useful in the field of treatment of various cancers as a kinase inhibitor, especially as a Weel kinase inhibitor.
(FR)La présente invention concerne les formes cristallines de 2-allyl-l-[6-(I-hydroxy-1-méthyléthyl)pyridin-2-yl]-6-{[4-(4-méthylpipérazin-l-yl)phényl]amino}-l,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one ou un sel de celle-ci, qui sont utiles dans le domaine du traitement de divers cancers en tant qu'inhibiteur de kinase, spécialement en tant qu'inhibiteur de la kinase Weel.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)