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1. WO2008129080 - 4, 6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES

Publication Number WO/2008/129080
Publication Date 30.10.2008
International Application No. PCT/EP2008/055017
International Filing Date 24.04.2008
IPC
C07D 239/42 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32One oxygen, sulfur or nitrogen atom
42One nitrogen atom
C07D 401/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 403/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 405/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 409/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
A61K 31/505 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
CPC
A61P 25/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
04Centrally acting analgesics, e.g. opioids
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
Applicants
  • INGENIUM PHARMACEUTICALS GMBH [DE]/[DE] (AllExceptUS)
  • WABNITZ, Philipp [DE]/[DE] (UsOnly)
  • SCHAUERTE, Heike [DE]/[DE] (UsOnly)
  • ALLGEIER, Hans [DE]/[DE] (UsOnly)
  • AUGUSTIN, Martin [DE]/[DE] (UsOnly)
  • ZEITLMANN, Lutz [DE]/[DE] (UsOnly)
  • PLEISS, Michael A. [US]/[US] (UsOnly)
  • STUMM, Gabriele [DE]/[DE] (UsOnly)
  • MUELLER, Anke [DE]/[DE] (UsOnly)
  • CHOIDAS, Axel [DE]/[DE] (UsOnly)
  • KLEBL, Bert [DE]/[DE] (UsOnly)
  • MUELLER, Gerhard [DE]/[DE] (UsOnly)
  • SCHWAB, Wilfried [DE]/[DE] (UsOnly)
  • LE, Joelle [GB]/[GB] (UsOnly)
  • MACRITCHIE, Jackie [GB]/[GB] (UsOnly)
  • SIMPSON, Don [GB]/[GB] (UsOnly)
Inventors
  • WABNITZ, Philipp
  • SCHAUERTE, Heike
  • ALLGEIER, Hans
  • AUGUSTIN, Martin
  • ZEITLMANN, Lutz
  • PLEISS, Michael A.
  • STUMM, Gabriele
  • MUELLER, Anke
  • CHOIDAS, Axel
  • KLEBL, Bert
  • MUELLER, Gerhard
  • SCHWAB, Wilfried
  • LE, Joelle
  • MACRITCHIE, Jackie
  • SIMPSON, Don
Agents
  • HOFFMANN, Matthias
Priority Data
07106951.225.04.2007EP
PCT/EP2007/00360824.04.2007EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) 4, 6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES
(FR) INHIBITEURS DE PROTÉINE KINASES
Abstract
(EN) The present invention relates to inhibitors of general Formula (I) of cyclin-dependent kinases and therapeutic applications thereof. Furthermore, the invention relates to compounds for preventing and/or treating any type of pain, inflammatory disorders, immunological diseases, proliferative diseases, infectious diseases, cardiovascular diseases and neurodegenerative diseases.
(FR) La présente invention porte sur des inhibiteurs de kinases dépendantes de cyclines et sur leurs applications thérapeutiques. De plus, l'invention porte sur des procédés pour prévenir et/ou traiter n'importe quel type de douleur, troubles inflammatoires, maladies immunologiques, maladies prolifératives, maladies infectieuses, maladies cardiovasculaires et maladies neurodégénératives, comprenant l'administration d'une quantité efficace d'au moins un inhibiteur de kinases dépendantes de cyclines.
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