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1. WO2008129080 - 4, 6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES

Publication Number WO/2008/129080
Publication Date 30.10.2008
International Application No. PCT/EP2008/055017
International Filing Date 24.04.2008
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32
One oxygen, sulfur or nitrogen atom
42
One nitrogen atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C07D 239/42 (2006.01)
C07D 401/12 (2006.01)
C07D 403/12 (2006.01)
C07D 405/12 (2006.01)
C07D 409/12 (2006.01)
A61K 31/505 (2006.01)
CPC
C07D 239/42
C07D 239/48
C07D 401/12
C07D 403/12
C07D 405/12
C07D 409/12
Applicants
  • INGENIUM PHARMACEUTICALS GMBH [DE/DE]; Fraunhoferstrasse 13 82152 Martinsried, DE (AllExceptUS)
  • WABNITZ, Philipp [DE/DE]; DE (UsOnly)
  • SCHAUERTE, Heike [DE/DE]; DE (UsOnly)
  • ALLGEIER, Hans [DE/DE]; DE (UsOnly)
  • AUGUSTIN, Martin [DE/DE]; DE (UsOnly)
  • ZEITLMANN, Lutz [DE/DE]; DE (UsOnly)
  • PLEISS, Michael A. [US/US]; US (UsOnly)
  • STUMM, Gabriele [DE/DE]; DE (UsOnly)
  • MUELLER, Anke [DE/DE]; DE (UsOnly)
  • CHOIDAS, Axel [DE/DE]; DE (UsOnly)
  • KLEBL, Bert [DE/DE]; DE (UsOnly)
  • MUELLER, Gerhard [DE/DE]; DE (UsOnly)
  • SCHWAB, Wilfried [DE/DE]; DE (UsOnly)
  • LE, Joelle [GB/GB]; GB (UsOnly)
  • MACRITCHIE, Jackie [GB/GB]; GB (UsOnly)
  • SIMPSON, Don [GB/GB]; GB (UsOnly)
Inventors
  • WABNITZ, Philipp; DE
  • SCHAUERTE, Heike; DE
  • ALLGEIER, Hans; DE
  • AUGUSTIN, Martin; DE
  • ZEITLMANN, Lutz; DE
  • PLEISS, Michael A.; US
  • STUMM, Gabriele; DE
  • MUELLER, Anke; DE
  • CHOIDAS, Axel; DE
  • KLEBL, Bert; DE
  • MUELLER, Gerhard; DE
  • SCHWAB, Wilfried; DE
  • LE, Joelle; GB
  • MACRITCHIE, Jackie; GB
  • SIMPSON, Don; GB
Agents
  • HOFFMANN, Matthias; Probiodrug AG Weinbergweg 22 06120 Halle / Saale, DE
Priority Data
07106951.225.04.2007EP
PCT/EP2007/00360824.04.2007EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 4, 6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES
(FR) INHIBITEURS DE PROTÉINE KINASES
Abstract
(EN)
The present invention relates to inhibitors of general Formula (I) of cyclin-dependent kinases and therapeutic applications thereof. Furthermore, the invention relates to compounds for preventing and/or treating any type of pain, inflammatory disorders, immunological diseases, proliferative diseases, infectious diseases, cardiovascular diseases and neurodegenerative diseases.
(FR)
La présente invention porte sur des inhibiteurs de kinases dépendantes de cyclines et sur leurs applications thérapeutiques. De plus, l'invention porte sur des procédés pour prévenir et/ou traiter n'importe quel type de douleur, troubles inflammatoires, maladies immunologiques, maladies prolifératives, maladies infectieuses, maladies cardiovasculaires et maladies neurodégénératives, comprenant l'administration d'une quantité efficace d'au moins un inhibiteur de kinases dépendantes de cyclines.
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