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1. (WO2008125833) PHARMACEUTICAL COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2008/125833 International Application No.: PCT/GB2008/001292
Publication Date: 23.10.2008 International Filing Date: 14.04.2008
IPC:
C07D 401/14 (2006.01) ,C07D 403/04 (2006.01) ,C07D 403/14 (2006.01) ,C07D 409/14 (2006.01) ,C07D 487/04 (2006.01) ,A61K 31/5377 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5375
1,4-Oxazines, e.g. morpholine
5377
not condensed and containing further heterocyclic rings, e.g. timolol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
BAKER, Stewart, James [GB/GB]; GB (UsOnly)
GOLDSMITH, Paul, John [GB/GB]; GB (UsOnly)
HANCOX, Timothy, Colin [GB/GB]; GB (UsOnly)
PEGG, Neil, Anthony [GB/GB]; GB (UsOnly)
SHUTTLEWORTH, Stephen, Joseph [GB/GB]; GB (UsOnly)
DECHAUX, Elsa, Amandine [FR/GB]; GB (UsOnly)
KRINTEL, Sussie, Lerche [DK/GB]; GB (UsOnly)
PRICE, Stephen [GB/GB]; GB (UsOnly)
LARGE, Jonathan, Martin [GB/GB]; GB (UsOnly)
MCDONALD, Edward [GB/GB]; GB (UsOnly)
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel, CH (AllExceptUS)
THE INSTITUTE OF CANCER RESEARCH [GB/GB]; Royal Cancer Hospital 123 Old Brompton Road London SW7 3RP, GB (AllExceptUS)
Inventors:
BAKER, Stewart, James; GB
GOLDSMITH, Paul, John; GB
HANCOX, Timothy, Colin; GB
PEGG, Neil, Anthony; GB
SHUTTLEWORTH, Stephen, Joseph; GB
DECHAUX, Elsa, Amandine; GB
KRINTEL, Sussie, Lerche; GB
PRICE, Stephen; GB
LARGE, Jonathan, Martin; GB
MCDONALD, Edward; GB
Agent:
KEEN, Celia, Mary; J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5JJ, GB
Priority Data:
0707086.512.04.2007GB
0707613.619.04.2007GB
Title (EN) PHARMACEUTICAL COMPOUNDS
(FR) COMPOSÉS PHARMACEUTIQUES
Abstract:
(EN) The invention provides a compound which is a pyrimidine of formula (I): The compounds are inhibitors of PI3K and may thus be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.
(FR) La présente invention concerne un composé qui est une pyrimidine de formule (I). Les composés sont inhibiteurs de PI3K et peuvent donc être utilisés pour traiter des maladies et des troubles provoqués par une croissance cellulaire anormale, une fonction ou un comportement associé(e) à la PI3 kinase tels que le cancer, des troubles immunitaires, une maladie cardiovasculaire, une infection virale, l'inflammation, des troubles de la fonction métabolique/endocrinienne et des troubles neurologiques.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)