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1. WO2008122789 - METHODS FOR MODULATING LRRK2

Publication Number WO/2008/122789
Publication Date 16.10.2008
International Application No. PCT/GB2008/001211
International Filing Date 07.04.2008
IPC
C12Q 1/48 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
48involving transferase
C07K 14/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
CPC
A61P 25/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C12Q 1/485
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
48involving transferase
485involving kinase
Applicants
  • MEDICAL RESEARCH COUNCIL [GB]/[GB] (AllExceptUS)
  • ALESSI, Dario [GB]/[GB] (UsOnly)
Inventors
  • ALESSI, Dario
Agents
  • PILKINGTON, Stephanie
Priority Data
0706709.305.04.2007GB
60/910,24205.04.2007US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR MODULATING LRRK2
(FR) PROCÉDÉS
Abstract
(EN)
A method for identifying a compound expected to be useful in modulating a LRRK2 protein kinase activity, the method comprising the steps of (1) determining whether a test compound modulates the protein kinase activity of a LRRK2 polypeptide on a substrate Ezrin/Radixin/moesin (ERM) family polypeptide and (2) selecting a compound which modulates the LRRK2 polypeptide protein kinase activity. Such a compound may be useful in treating Parkinson's Disease or Parkinsonism. A catalytically active fragment of LRRK2 is identified, requiring the GTPase, COR and kinase domains as well as the WD_40-like motif and C-terminal tail.
(FR)
L'invention concerne un procédé permettant d'identifier un composé dont on espère qu'il convienne pour moduler l'activité protéine kinase de LRRK2, ce procédé comprenant les étapes (1) de la détermination permettant de savoir si un composé test module l'activité protéine kinase d'un polypeptide LRRK2 sur un polypeptide substrat de la famille Ezrine/Radixine/moesine (ERM) et (2) de la sélection d'un composé qui module l'activité protéine kinase du polypeptide LRRK2. Ce composé peut convenir pour le traitement de la maladie de Parkinson ou pour le parkinsonisme. Un fragment catalytiquement actif de LRRk2 est identifié, nécessitant les domaines GTPase, COR et kinase ainsi que le motif de type WD-40 et la terminaison C-terminal.
Also published as
US12244715
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