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1. (WO2008122038) REGULATING AUTOPHAGY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2008/122038 International Application No.: PCT/US2008/059129
Publication Date: 09.10.2008 International Filing Date: 02.04.2008
IPC:
A61K 31/405 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
404
Indoles, e.g. pindolol
405
Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
Applicants:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street Cambridge, MA 02139, US (AllExceptUS)
DANA-FARBER CANCER INSTITUTE, INC. [US/US]; 44 Binney Street Boston, MA 02115, US (AllExceptUS)
CAMBRIDGE ENTERPRISE LTD. [GB/GB]; The Old Schools Trinity Lane Cambridge CB2 1TN, GB (AllExceptUS)
YALE UNIVERSITY [US/US]; 433 Temple Street, First Floor New Haven, CT 06511, US (AllExceptUS)
BRADNER, James, Elliot [US/US]; US (UsOnly)
SHEN, John, Paul [US/US]; US (UsOnly)
PERLSTEIN, Ethan, Oren [US/US]; US (UsOnly)
RUBINSZTEIN, David [GB/GB]; GB (UsOnly)
SARKAR, Sovan [IN/IN]; IN (UsOnly)
SCHREIBER, Stuart, L. [US/US]; US (UsOnly)
WOOD, John [US/US]; US (UsOnly)
Inventors:
BRADNER, James, Elliot; US
SHEN, John, Paul; US
PERLSTEIN, Ethan, Oren; US
RUBINSZTEIN, David; GB
SARKAR, Sovan; IN
SCHREIBER, Stuart, L.; US
WOOD, John; US
Agent:
BAKER, C., Hunter; Wolf, Greenfield & Sacks, P.C. Federal Reserve Plazza 600 Atlantic Avenue Boston, MA 02210-2206, US
Priority Data:
60/909,64002.04.2007US
Title (EN) REGULATING AUTOPHAGY
(FR) AUTOPHAGIE RÉGULATRICE
Abstract:
(EN) Autophagy is a cellular process by which cells canabalize non-essential cellular elements such as organelles to generate metabolites, or in some cases, to cause cell death. The present invention provides modulators of autophagy, which have been identified using a high-throughput phenotypic screen of over 3500 compounds. These modulators are useful in treating diseases ranging from proliferative diseases to neurodegenerative diseases to infectious diseases to protein misfolding states. Furthermore, the invention provides the treatment of proliferative disease such as cancer with a combination of autophagy inhibitors and protein kinase inhibitors.
(FR) L'invention concerne l'autophagie, qui est un processus cellulaire par lequel des cellules cannibalisent des éléments cellulaires non essentiels tels que des organelles pour générer des métabolites, ou dans certains cas, pour provoquer une mort cellulaire. La présente invention propose des modulateurs de l'autophagie, qui ont été identifiés en utilisant un criblage phénotypique de capacité élevée sur plus de 3 500 composés. Ces modulateurs sont utiles pour traiter des maladies allant des maladies prolifératives aux maladies neurodégénératives jusqu'aux maladies infectieuses à des états de mauvais repliement de protéine. De plus, l'invention propose un traitement d'une maladie proliférative telle que le cancer avec une combinaison d'inhibiteurs d'autophagie et d'inhibiteurs de protéine kinase.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)