Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2008118808) LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2008/118808 International Application No.: PCT/US2008/057902
Publication Date: 02.10.2008 International Filing Date: 21.03.2008
IPC:
G01N 30/80 (2006.01) ,G01N 30/72 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30
Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02
Column chromatography
80
Fraction collectors
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30
Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02
Column chromatography
62
Detectors specially adapted therefor
72
Mass spectrometers
Applicants:
ADVION BIOSCIENCE, INC. [US/US]; 19 Brown Rd. Ithaca, NY 14850, US (AllExceptUS)
SCHULTZ, Gary, A. [US/US]; US (UsOnly)
QUEIROS DE ALMEIDA, Reinaldo, Rodrigo [DE/DE]; DE (UsOnly)
ALLEN, Mark, Hayden [GB/GB]; GB (UsOnly)
Inventors:
SCHULTZ, Gary, A.; US
QUEIROS DE ALMEIDA, Reinaldo, Rodrigo; DE
ALLEN, Mark, Hayden; GB
Agent:
DALEY, Sean, P. ; FISH & RICHARDSON P.C. P.O Box 1022 Minneaplis, MN 55440-1022, US
Priority Data:
60/896,69223.03.2007US
Title (EN) LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY
(FR) SYSTÈME DE SPECTROMÉTRIE DE MASSE ET DE CHROMATOGRAPHIE LIQUIDE
Abstract:
(EN) A liquid chromatography/mass spectrometry system includes a chromatographic column (12) through which an effluent passes, wherein the effluent comprises a plurality of analytes that correspond to a plurality of chromatographic peaks and an eluent; a post-column splitter (14) having at least two output ports through which the effluent of the column is split to at least a first portion and a second portion; a mass spectrometer configured to receive the first portion from a first of the output ports for analysis; and a tube (10) connected to a second of the output ports configured to prevent substantial evaporation of the eluent in the second portion until undergoing mass spectrometry. The second portion has a plurality of separated analytes corresponding to at least two chromatographic peaks. A method of using the system is also disclosed.
(FR) L'invention concerne un système de spectrométrie de masse et de chromatographie liquide qui inclut une colonne de chromatographie (12) à travers laquelle passe un effluent, ledit effluent comprenant une pluralité d'analytes qui correspondent à une pluralité de pics de chromatographie et un éluant; une colonne de séparation post-colonne (14) comportant au moins deux orifices de sortie à travers laquelle l'effluent de la colonne est divisé en au moins une première partie et une seconde partie; un spectromètre de masse configuré pour recevoir la première partie provenant d'un premier des deux orifices de sortie en vue d'une analyse; et un tube (10) relié à un second des orifices de sortie configuré pour empêcher une évaporation importante de l'éluant dans la seconde partie jusqu'au moment de son analyse par spectrométrie de masse. La seconde partie contient une pluralité d'analytes séparés qui correspondent à au moins deux pics de chromatographie. L'invention concerne également un procédé d'utilisation du système.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)