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1. (WO2008118327) CONFORMATIONALLY RESTRAINED EPOTHILONE ANALOGUES AS ANTI-LEUKEMIC AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2008/118327 International Application No.: PCT/US2008/003638
Publication Date: 02.10.2008 International Filing Date: 20.03.2008
IPC:
A61K 31/335 (2006.01) ,C07D 487/00 (2006.01) ,C07D 225/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
225
Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
04
condensed with carbocyclic rings or ring systems
Applicants:
TILLEKERATNE, Viranga [US/US]; US (UsOnly)
HUDSON, Richard, A. [US/US]; US (UsOnly)
ALHAMADSHEH, Mamoun [JO/US]; US (UsOnly)
UNIVERSITY OF TOLEDO [US/US]; A University Instrumentality of the State of Ohio 2801 W. Bancroft Avenue Toledo, OH 43606, US (AllExceptUS)
Inventors:
TILLEKERATNE, Viranga; US
HUDSON, Richard, A.; US
ALHAMADSHEH, Mamoun; US
Agent:
MARTINEAU, Catherine, B.; MacMillian, Sobanski & Todd, LLC One Maritime Plaza; 5th Floor 720 Water Street Toledo, OH 43604, US
Priority Data:
60/919,80423.03.2007US
Title (EN) CONFORMATIONALLY RESTRAINED EPOTHILONE ANALOGUES AS ANTI-LEUKEMIC AGENTS
(FR) ANALOGUES D'ÉPOTHILONE RESTREINTS EN CONFORMATION EN TANT QU'AGENTS ANTI-LEUCÉMIQUES
Abstract:
(EN) A method for synthesizing anti-leukemic epothilone analogues includes rigidifying a region between the macrolactone ring and the aromatic side-chain. The anti-leukemic compositions are non-naturally occurring epothilone analogue that are rigidified between the macrolactone ring and the aromatic side-chain.
(FR) L'invention concerne un procédé pour synthétiser des analogues épothilone anti-leucémiques comprenant la rigidification d'une région entre le cycle de macrolactone et la chaîne latérale aromatique. Les compositions anti-leucémiques sont des analogues d'épothilone non présents à l'état naturel qui sont rigidifiés entre le cycle de macrolactone et la chaîne latérale aromatique.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)