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1. (WO2008113795) COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2008/113795 International Application No.: PCT/EP2008/053194
Publication Date: 25.09.2008 International Filing Date: 18.03.2008
IPC:
C07D 231/56 (2006.01) ,C07D 401/04 (2006.01) ,C07D 401/14 (2006.01) ,C07D 403/10 (2006.01) ,C07D 417/10 (2006.01) ,A61K 31/416 (2006.01) ,A61P 25/00 (2006.01) ,C07D 231/12 (2006.01) ,C07D 231/54 (2006.01) ,C07D 493/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
231
Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
54
condensed with carbocyclic rings or ring systems
56
Benzopyrazoles; Hydrogenated benzopyrazoles
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
10
linked by a carbon chain containing aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
10
linked by a carbon chain containing aromatic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
416
condensed with carbocyclic ring systems, e.g. indazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
231
Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
02
not condensed with other rings
10
having two or three double bonds between ring members or between ring members and non-ring members
12
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
231
Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
54
condensed with carbocyclic rings or ring systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House Berkeley Avenue Greenford Middlesex UB6 0NN, GB (AllExceptUS)
BERTHELEME, Nicolas [FR/GB]; GB (UsOnly)
BRADLEY, Daniel, Marcus [GB/GB]; GB (UsOnly)
CARDULLO, Francesca [IT/IT]; IT (UsOnly)
MERLO, Giancarlo [IT/IT]; IT (UsOnly)
POZZAN, Alfonso [IT/IT]; IT (UsOnly)
SCOTT, Jaqueline, Sandra [GB/GB]; GB (UsOnly)
THEWLIS, Kevin, Michael [GB/GB]; GB (UsOnly)
WARD, Simon, Edward [GB/GB]; GB (UsOnly)
Inventors:
BERTHELEME, Nicolas; GB
BRADLEY, Daniel, Marcus; GB
CARDULLO, Francesca; IT
MERLO, Giancarlo; IT
POZZAN, Alfonso; IT
SCOTT, Jaqueline, Sandra; GB
THEWLIS, Kevin, Michael; GB
WARD, Simon, Edward; GB
Agent:
KONDO, Rie ; GlaxoSmithKline Corporate Intellectual Property (CN925.1) 980 Great West Road Brentford Middlesex TW8 9GS, GB
Priority Data:
0705330.920.03.2007GB
0710874.906.06.2007GB
0718199.318.09.2007GB
0719000.228.09.2007GB
Title (EN) COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE
(FR) COMPOSÉS POTENTIALISANT LE RÉCEPTEUR AMPA ET LEURS UTILISATIONS EN MÉDECINE
Abstract:
(EN) Compound of formula (I) and salts thereof are provided: wherein A, R1, R, R2 are as defined in the specification. Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.
(FR) L'invention concerne un composé représenté par la formule (I), ainsi que ses sels. Dans ladite formule, A, R1, R, R2 correspondent à leur définition du descriptif. Elle concerne également des procédés de préparation, des compositions pharmaceutiques et leurs utilisations sous forme de médicament, par exemple, pour traiter une maladie ou un état résultant d'une diminution ou d'un déséquilibre de la fonction du récepteur de glutamate, tels que la schizophrénie ou le déficit cognitif.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)