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Machine translation
1. (WO2008110846) COMPOSITIONS COMPRISING (S)-2-AMINO-1-(4-CHLOROPHENYL)-1-[4-(1H-PYRAZOL-4-YL)-PHENYL]-ETHANOL AS MODULATOR OF PROTEIN KINASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/110846    International Application No.:    PCT/GB2008/050180
Publication Date: 18.09.2008 International Filing Date: 14.03.2008
IPC:
A61K 31/415 (2006.01), C07D 231/12 (2006.01), C07D 301/00 (2006.01), A61P 35/00 (2006.01)
Applicants: ASTEX THERAPEUTICS LIMITED [GB/GB]; 436 Cambridge Science Park, Milton Road, Cambridge Cambridgeshire CB4 0QA (GB) (For All Designated States Except US).
THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL [GB/GB]; 123 Old Brompton Road, London SW7 3RP (GB) (For All Designated States Except US).
CANCER RESEARCH TECHNOLOGY LIMITED [GB/GB]; Sardinia House, Sardinia Street, London WC2A 3NL (GB) (For All Designated States Except US).
WOODHEAD, Steven John [GB/GB]; (GB) (For US Only).
REES, David Charles [GB/GB]; (GB) (For US Only).
FREDERICKSON, Martyn [GB/GB]; (GB) (For US Only).
GRIMSHAW, Kyla Merriom [GB/GB]; (GB) (For US Only)
Inventors: WOODHEAD, Steven John; (GB).
REES, David Charles; (GB).
FREDERICKSON, Martyn; (GB).
GRIMSHAW, Kyla Merriom; (GB)
Agent: HUTCHINS, Michael Richard; Elkington And Fife LLP, Prospect House, 8 Pembroke Road, Sevenoaks Kent TN13 1XR (GB)
Priority Data:
0704932.3 14.03.2007 GB
60/894,752 14.03.2007 US
Title (EN) COMPOSITIONS COMPRISING (S)-2-AMINO-1-(4-CHLOROPHENYL)-1-[4-(1H-PYRAZOL-4-YL)-PHENYL]-ETHANOL AS MODULATOR OF PROTEIN KINASES
(FR) COMPOSÉS PHARMACEUTIQUES
Abstract: front page image
(EN)The invention provides a composition comprising (S) 2-amino-1-(4-chloro-phenyl)- 1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, wherein the composition is either substantially free of (R) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)- phenyl]-ethanol or the composition contains a mixture of the (S) and (R) enantiomers in which the (S) enantiomer predominates. Also provided are processes for the preparation of the (S) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H- pyrazol-4-yl)-phenyl]-ethanol, novel process intermediates and methods for making the novel process intermediates.
(FR)L'invention concerne une composition qui contient (S) 2-amino-1-(4-chloro-phényl)- 1-[4-(1H-pyrazol-4-yl)-phényl]-éthanol, cette composition étant soit pratiquement exempte de (R) 2-amino-1-(4-chloro-phényl)-1-[4-(1H-pyrazol-4-yl)- phényl]-éthanol soit contient un mélange des énantiomères (S) et (R) où l'énantiomère (S) prédomine. De plus, l'invention concerne des procédés de préparation de (S) 2-amino-1-(4-chloro-phényl)-1-[4-(1H- pyrazol-4-yl)-phényl]-éthanol, de nouveaux intermédiaires de processus ainsi que des procédés de préparation de ces nouveaux intermédiaires de processus.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)