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1. (WO2008107478) QUINOLINONE DERIVATIVES AS PARP AND TANK INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2008/107478 International Application No.: PCT/EP2008/052764
Publication Date: 12.09.2008 International Filing Date: 07.03.2008
IPC:
C07D 215/22 (2006.01) ,A61K 31/4704 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20
Oxygen atoms
22
attached in position 2 or 4
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
4704
2-Quinolinones, e.g. carbostyril
Applicants:
VIALARD, Jorge Eduardo [CA/BE]; BE (UsOnly)
ANGIBAUD, Patrick René [FR/FR]; FR (UsOnly)
MEVELLEC, Laurence Anne [FR/FR]; FR (UsOnly)
MEYER, Christophe [FR/FR]; FR (UsOnly)
FREYNE, Eddy Jean Edgard [BE/BE]; BE (UsOnly)
PILATTE, Isabelle Noëlle Constance [FR/FR]; FR (UsOnly)
ROUX, Bruno [FR/FR]; FR (UsOnly)
PASQUIER, Elisabeth Thérèse Jeanne [FR/FR]; FR (UsOnly)
BOURDREZ, Xavier Marc [FR/FR]; FR (UsOnly)
ADELINET, Christophe Denis [FR/FR]; FR (UsOnly)
MARCONNET-DECRANE, Laurence Françoise Bernadette [FR/FR]; FR (UsOnly)
MACRITCHIE, Jacqueline Anne [GB/GB]; GB (UsOnly)
DUFFY, James Edward Stewart [GB/GB]; GB (UsOnly)
OWENS, Andrew Pate [GB/GB]; GB (UsOnly)
STORCK, Pierre-Henri [FR/FR]; FR (UsOnly)
PONCELET, Virginie Sophie [FR/FR]; FR (UsOnly)
JANSSEN PHARMACEUTICA NV [BE/BE]; Turnhoutseweg 30 B-2340 Beerse, BE (AllExceptUS)
Inventors:
VIALARD, Jorge Eduardo; BE
ANGIBAUD, Patrick René; FR
MEVELLEC, Laurence Anne; FR
MEYER, Christophe; FR
FREYNE, Eddy Jean Edgard; BE
PILATTE, Isabelle Noëlle Constance; FR
ROUX, Bruno; FR
PASQUIER, Elisabeth Thérèse Jeanne; FR
BOURDREZ, Xavier Marc; FR
ADELINET, Christophe Denis; FR
MARCONNET-DECRANE, Laurence Françoise Bernadette; FR
MACRITCHIE, Jacqueline Anne; GB
DUFFY, James Edward Stewart; GB
OWENS, Andrew Pate; GB
STORCK, Pierre-Henri; FR
PONCELET, Virginie Sophie; FR
Common
Representative:
JANSSEN PHARMACEUTICA NV; Turnhoutseweg 30 B-2340 Beerse, BE
Priority Data:
07103788.108.03.2007EP
60/893,68008.03.2007US
Title (EN) QUINOLINONE DERIVATIVES AS PARP AND TANK INHIBITORS
(FR) DÉRIVÉS DE QUINOLINONE COMME INHIBITEURS DE PARP ET DE TANK
Abstract:
(EN) The present invention provides compounds of Formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds, wherein R1, R2, R3, R4, R5, R6, R7, n, m and X have defined meanings.
(FR) La présente invention porte sur des composés de Formule (I), sur leur utilisation comme inhibiteurs de PARP ainsi que sur des compositions pharmaceutiques comprenant lesdits composés, où R1, R2, R3, R4, R5, R6, R7, n, m et X ont les significations définies.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)