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1. WO2008107478 - QUINOLINONE DERIVATIVES AS PARP AND TANK INHIBITORS

Publication Number WO/2008/107478
Publication Date 12.09.2008
International Application No. PCT/EP2008/052764
International Filing Date 07.03.2008
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20
Oxygen atoms
22
attached in position 2 or 4
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
4704
2-Quinolinones, e.g. carbostyril
C07D 215/22 (2006.01)
A61K 31/4704 (2006.01)
CPC
C07D 215/227
C07D 401/06
C07D 401/12
C07D 405/06
C07D 409/06
C07D 413/06
Applicants
  • JANSSEN PHARMACEUTICA NV [BE/BE]; Turnhoutseweg 30 B-2340 Beerse, BE (AllExceptUS)
  • VIALARD, Jorge Eduardo [CA/BE]; BE (UsOnly)
  • ANGIBAUD, Patrick René [FR/FR]; FR (UsOnly)
  • MEVELLEC, Laurence Anne [FR/FR]; FR (UsOnly)
  • MEYER, Christophe [FR/FR]; FR (UsOnly)
  • FREYNE, Eddy Jean Edgard [BE/BE]; BE (UsOnly)
  • PILATTE, Isabelle Noëlle Constance [FR/FR]; FR (UsOnly)
  • ROUX, Bruno [FR/FR]; FR (UsOnly)
  • PASQUIER, Elisabeth Thérèse Jeanne [FR/FR]; FR (UsOnly)
  • BOURDREZ, Xavier Marc [FR/FR]; FR (UsOnly)
  • ADELINET, Christophe Denis [FR/FR]; FR (UsOnly)
  • MARCONNET-DECRANE, Laurence Françoise Bernadette [FR/FR]; FR (UsOnly)
  • MACRITCHIE, Jacqueline Anne [GB/GB]; GB (UsOnly)
  • DUFFY, James Edward Stewart [GB/GB]; GB (UsOnly)
  • OWENS, Andrew Pate [GB/GB]; GB (UsOnly)
  • STORCK, Pierre-Henri [FR/FR]; FR (UsOnly)
  • PONCELET, Virginie Sophie [FR/FR]; FR (UsOnly)
Inventors
  • VIALARD, Jorge Eduardo; BE
  • ANGIBAUD, Patrick René; FR
  • MEVELLEC, Laurence Anne; FR
  • MEYER, Christophe; FR
  • FREYNE, Eddy Jean Edgard; BE
  • PILATTE, Isabelle Noëlle Constance; FR
  • ROUX, Bruno; FR
  • PASQUIER, Elisabeth Thérèse Jeanne; FR
  • BOURDREZ, Xavier Marc; FR
  • ADELINET, Christophe Denis; FR
  • MARCONNET-DECRANE, Laurence Françoise Bernadette; FR
  • MACRITCHIE, Jacqueline Anne; GB
  • DUFFY, James Edward Stewart; GB
  • OWENS, Andrew Pate; GB
  • STORCK, Pierre-Henri; FR
  • PONCELET, Virginie Sophie; FR
Common Representative
  • JANSSEN PHARMACEUTICA NV; Turnhoutseweg 30 B-2340 Beerse, BE
Priority Data
07103788.108.03.2007EP
60/893,68008.03.2007US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) QUINOLINONE DERIVATIVES AS PARP AND TANK INHIBITORS
(FR) DÉRIVÉS DE QUINOLINONE COMME INHIBITEURS DE PARP ET DE TANK
Abstract
(EN)
The present invention provides compounds of Formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds, wherein R1, R2, R3, R4, R5, R6, R7, n, m and X have defined meanings.
(FR)
La présente invention porte sur des composés de Formule (I), sur leur utilisation comme inhibiteurs de PARP ainsi que sur des compositions pharmaceutiques comprenant lesdits composés, où R1, R2, R3, R4, R5, R6, R7, n, m et X ont les significations définies.
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