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1. WO2008104781 - PROCESS FOR PREPARING ISOMERS OF CARMOTEROL

Publication Number WO/2008/104781
Publication Date 04.09.2008
International Application No. PCT/GB2008/000677
International Filing Date 28.02.2008
Chapter 2 Demand Filed 29.12.2008
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20
Oxygen atoms
22
attached in position 2 or 4
227
only one oxygen atom which is attached in position 2
C07D 215/227 (2006.01)
CPC
C07D 215/227
Applicants
  • CIPLA LIMITED [IN/IN]; 289 Bellasis Road Mumbai central Mumbai 400 008, IN (AllExceptUS)
  • CURTIS, Philip, Anthony [GB/GB]; A.A. Thornthon & Co. 235 High Holborn London WC1V 7LE, GB (MW)
  • KANKAN, Rajendra, Narayanrao [IN/IN]; IN (UsOnly)
  • RAO, Dharmaraj, Ramachandra [IN/IN]; IN (UsOnly)
  • BIRARI, Dilip [IN/IN]; IN (UsOnly)
  • SAWANT, Ashwini, Amol [IN/IN]; IN (UsOnly)
Inventors
  • KANKAN, Rajendra, Narayanrao; IN
  • RAO, Dharmaraj, Ramachandra; IN
  • BIRARI, Dilip; IN
  • SAWANT, Ashwini, Amol; IN
Agents
  • COTTRILL, Emily, Elizabeth, Helen; A.A. THORNTON & CO 235 High Holborn London WC1V 7LE, GB
Priority Data
391/MUM/200728.02.2007IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR PREPARING ISOMERS OF CARMOTEROL
(FR) PROCÉDÉ DE PRÉPARATION D'ISOMÈRES DE CARMOTÉROL
Abstract
(EN)
A process for preparing a compound of formula (III) comprising condensing an oxiranyl compound of formula (I) with an amine of formula (II) or a salt thereof wherein: R1 is a group selected from alkyl, aryl, allyl, alkoxy, cycloalkyl, heterocyclic, alkenyl, benzocycloalkyl, aralkyl, haloarylalkyl, heteroaralkyl, haloalkyl, alkoxyaralkyl, substituted silyl and benzyl; and R2 is hydrogen, optionally substituted silyl or optionally substituted benzyl. Formula (I), (II) & (III): There is also described a process for preparing (R,R)-carmoterol from compound (III).
(FR)
La présente invention concerne un procédé de préparation d'un composé de formule (III) comprenant la condensation d'un composé oxiranyle de formule (I) avec une amine de formule (II) ou un sel de celle-ci, dans laquelle: R1 est un groupe choisi parmi alkyle, aryle, allyle, alcoxy, cycloalkyle, hétérocyclique, alcényle, benzocycloalkyle, aralkyle, haloarylalkyle, hétéroaralkyle, haloalkyle, alcoxyaralkyle, silyle et benzyle substitués; R2 est hydrogène, silyle éventuellement substitué ou benzyle éventuellement substitué. L'invention concerne également un procédé de préparation de (R,R)-carmotérol à partir du composé de formule (III). Formules (I), (ii) et (III)
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