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Machine translation
1. (WO2008103693) CHEMICAL LINKERS WITH SINGLE AMINO ACIDS AND CONJUGATES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/103693    International Application No.:    PCT/US2008/054362
Publication Date: 28.08.2008 International Filing Date: 20.02.2008
IPC:
C07D 403/14 (2006.01), C07D 405/14 (2006.01), C07D 487/04 (2006.01), C07K 5/06 (2006.01), A61K 31/407 (2006.01), A61K 31/404 (2006.01), A61P 35/00 (2006.01)
Applicants: MEDAREX, INC. [US/US]; 707 State Road, Princeton, NJ 08540 (US) (For All Designated States Except US).
CHEN, Liang [US/US]; (US) (For US Only).
GANGWAR, Sanjeev [US/US]; (US) (For US Only).
GUERLAVAIS, Vincent [FR/US]; (US) (For US Only).
LONBERG, Nils [US/US]; (US) (For US Only).
ZHANG, Qian [US/US]; (US) (For US Only)
Inventors: CHEN, Liang; (US).
GANGWAR, Sanjeev; (US).
GUERLAVAIS, Vincent; (US).
LONBERG, Nils; (US).
ZHANG, Qian; (US)
Agent: BLACK, Bruce, E.; Darby & Darby P.C., P.O. Box 770, Church Street Station, New York, NY 10008-0770 (US)
Priority Data:
60/891,028 21.02.2007 US
Title (EN) CHEMICAL LINKERS WITH SINGLE AMINO ACIDS AND CONJUGATES THEREOF
(FR) LIANTS CHIMIQUES AVEC ACIDES AMINÉS UNIQUES ET CONJUGUÉS DE CEUX-CI
Abstract: front page image
(EN)The present disclosure provides drug-ligand conjugates that are potent cytotoxins and include a linker between the drug and ligand where the linker has a single amino acid. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
(FR)L'invention concerne des conjugués de médicament-ligand qui sont des cytotoxines puissantes et qui comprennent un liant entre le médicament et le ligand, le liant ayant un acide aminé unique. La description concerne également des compositions contenant les conjugués de médicament-ligand et des procédés de traitement utilisant ceux-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)