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1. (WO2008103636) IMIDAZOQUINOLINES AS DUAL LIPID KINASE AND MTOR INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/103636    International Application No.:    PCT/US2008/054236
Publication Date: 28.08.2008 International Filing Date: 19.02.2008
IPC:
A61K 31/4745 (2006.01), A61P 7/00 (2006.01), A61P 9/00 (2006.01), A61P 37/00 (2006.01), A61P 43/00 (2006.01), A61P 25/00 (2006.01), A61P 27/02 (2006.01), A61P 31/04 (2006.01), A61P 31/12 (2006.01), A61P 35/00 (2006.01), A61P 11/00 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35, CH-4056 Basel (CH) (For All Designated States Except US).
BRACHMANN, Saskia Maria [DE/CH]; (CH) (For US Only).
FINAN, Peter [GB/US]; (US) (For US Only).
FRITSCH, Christine [FR/FR]; (FR) (For US Only).
GARCIA-ECHEVERRIA, Carlos [ES/CH]; (CH) (For US Only).
MAIRA, Sauveur-Michel [FR/FR]; (FR) (For US Only).
MURPHY, Leon [US/US]; (US) (For US Only).
NICKLIN, Paul Leslie [GB/GB]; (GB) (For US Only)
Inventors: BRACHMANN, Saskia Maria; (CH).
FINAN, Peter; (US).
FRITSCH, Christine; (FR).
GARCIA-ECHEVERRIA, Carlos; (CH).
MAIRA, Sauveur-Michel; (FR).
MURPHY, Leon; (US).
NICKLIN, Paul Leslie; (GB)
Agent: DOHMANN, George R.; Novartis AG, Patent Department, One Health Plaza, Bldg. 104, East Hanover, New Jersey 07936 (US)
Priority Data:
60/890,641 20.02.2007 US
Title (EN) IMIDAZOQUINOLINES AS DUAL LIPID KINASE AND MTOR INHIBITORS
(FR) IMIDAZOQUINOLÉINES COMME INHIBITEURS DOUBLES DE KINASE LIPIDIQUE ET DE MTOR
Abstract: front page image
(EN)The invention relates to the use of compounds of formula: (I) in the treatment of mammalian target of rapamycin (mTOR) kinase dependent diseases, methods of use of said compounds in the treatment of said diseases in a warm-blooded animal, especially a human, pharmaceutical preparations comprising said compounds for the treatment of said diseases and said compounds for use in the treatment of said diseases.
(FR)L'invention concerne l'utilisation de composés de la formule : (I) dans le traitement de maladies dépendant de la kinase de la cible de la rapamycine chez les mammifères (mTOR), des procédés d'utilisation desdits composés dans le traitement desdites maladies chez un animal à sang chaud, spécialement un être humain, des préparations pharmaceutiques comportant lesdits composés pour le traitement desdites maladies et lesdits composés pour une utilisation dans le traitement desdites maladies.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)