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Machine translation
1. (WO2008103574) PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2008/103574    International Application No.:    PCT/US2008/053653
Publication Date: 28.08.2008 International Filing Date: 12.02.2008
IPC:
C07D 249/12 (2006.01), C07D 401/06 (2006.01), A61P 3/00 (2006.01), A61K 31/4196 (2006.01), A61K 31/4439 (2006.01)
Applicants: ELI LILLY AND COMPANY [US/US]; Lilly Corporate Center, Indianapolis, Indiana 46285 (US) (For All Designated States Except US).
PFEIFER, Lance, Allen [US/US]; (US) (For US Only).
MA, Tianwei [CN/US]; (US) (For US Only).
MANTLO, Nathan, Bryan [US/US]; (US) (For US Only).
MICHAEL, Laura, Frey [US/US]; (US) (For US Only).
MOKUBE, Fese, Mambo [US/US]; (US) (For US Only).
MONTROSE-RAFIZADEH, Chahrzad [US/US]; (US) (For US Only)
Inventors: PFEIFER, Lance, Allen; (US).
MA, Tianwei; (US).
MANTLO, Nathan, Bryan; (US).
MICHAEL, Laura, Frey; (US).
MOKUBE, Fese, Mambo; (US).
MONTROSE-RAFIZADEH, Chahrzad; (US)
Agent: VORNDRAN-JONES, MaCharri; ELI LILLY AND COMPANY, P.O. Box 6288, Indianapolis, Indiana 46206-6288 (US)
Priority Data:
60/891,261 23.02.2007 US
Title (EN) PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS
(FR) MODULATEURS DU RÉCEPTEUR AU FACTEUR ACTIVÉ DE PROLIFÉRATION DES PEROXYSOMES
Abstract: front page image
(EN)The present invention is directed to compounds of the structural Formula: wherein: R1 is H or -C1-C3 alkyl; R2 is selected from the group consisting of -H, -C1-C4 alkyl, -C1-C3 alkyl-CF3, phenyl, and pyridinyl; and R3 is selected from the group consisting of -H, -C1-C4 alkyl, -C1-C3 alkyl-O-CH3, -CH2-cyclopropyl, -CH2-C=CH2, -CH2CH2-(2-F-phenyl), and phenyl substituted with from 1 to 2 fluorines; provided that when R1 and R2 are each H, then R3 is selected from the group consisting of -C1-C4 alkyl, -C1-C3 alkyl-O-CH3, -CH2-cyclopropyl, -CH2-C=CH2, -CH2CH2-(2-F-phenyl), and phenyl substituted with from 1 to 2 fluorines; or stereoisomers and pharmaceutically acceptable salts thereof.
(FR)La présente invention concerne des composés de formule structurale : dans laquelle : R1 représente H ou -C1-C3 alkyle ; R2 est sélectionné dans le groupe constitué de -H, -C1-C4 alkyle, -C1-C3 alkyle-CF3, phényle et pyridinyle ; et R3 est sélectionné dans le groupe constitué de -H, -C1-C4 alkyle, -C1-C3 alkyle-O-CH3, -CH2-cyclopropyle, -CH2-C=CH2, -CH2CH2-(2-F-phényle) et phényle substitué par 1 à 2 fluors ; à condition que lorsque R1 et R2 représentent chacun H, alors R3 est sélectionné dans le groupe constitué de -C1-C4 alkyle, -C1-C3 alkyle-O-CH3, -CH2-cyclopropyle, -CH2-C=CH2, -CH2CH2-(2-F-phényle) et phényle substitué par 1 à 2 fluors ; ou leurs stéréoisomères et leurs sels pharmaceutiquement acceptables.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)